Seasonal and 2009 pandemic influenza A (H1N1) virus infection during pregnancy: A population-based study of hospitalized cases

Andreea A. Creanga, Laurie Kamimoto, Kimberly Newsome, Tiffany D'Mello, Denise J. Jamieson, Marianne E. Zotti, Kathryn E. Arnold, Joan Baumbach, Nancy M. Bennett, Monica M. Farley, Ken Gershman, David Kirschke, Ruth Lynfield, James Meek, Craig Morin, Arthur Reingold, Patricia Ryan, William Schaffner, Ann Thomas, Shelley ZanskyLyn Finelli, Margaret A. Honein

Research output: Contribution to journalReview articlepeer-review


We sought to describe characteristics of hospitalized reproductive-aged (15-44 years) women with seasonal (2005/2006 through 2008/2009) and 2009 pandemic influenza A (H1N1) virus infection. We used population-based data from the Emerging Infections Program in 10 US states, and compared characteristics of pregnant (n = 150) and nonpregnant (n = 489) seasonal, and pregnant (n = 489) and nonpregnant (n = 1088) pandemic influenza cases using χ 2 and Fisher's exact tests. Pregnant women represented 23.5% and 31.0% of all reproductive-aged women hospitalized for seasonal and pandemic influenza, respectively. Significantly more nonpregnant than pregnant women with seasonal (71.2% vs 36.0%) and pandemic (69.7% vs 31.9%) influenza had an underlying medical condition other than pregnancy. Antiviral treatment was significantly more common with pandemic than seasonal influenza for both pregnant (86.5% vs 24.0%) and nonpregnant (82.0% vs 55.2%) women. Pregnant women comprised a significant proportion of influenza-hospitalized reproductive-aged women, underscoring the importance of influenza vaccination during pregnancy.

Original languageEnglish (US)
Pages (from-to)S38-S45
JournalAmerican journal of obstetrics and gynecology
Issue number6 SUPPL.
StatePublished - Jun 2011
Externally publishedYes


  • 2009 pandemic influenza
  • human
  • infectious
  • influenza
  • pregnancy
  • pregnancy complications
  • seasonal influenza

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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