Searching for differentially expressed gene combinations.

Marcel Dettling, Edward Gabrielson, Giovanni Parmigiani

Research output: Contribution to journalArticlepeer-review

Abstract

We propose 'CorScor', a novel approach for identifying gene pairs with joint differential expression. This is defined as a situation with good phenotype discrimination in the bivariate, but not in the two marginal distributions. CorScor can be used to detect phenotype-related dependencies and interactions among genes. Our easily interpretable approach is scalable to current microarray dimensions and yields promising results on several cancer-gene-expression datasets.

Original languageEnglish (US)
Pages (from-to)R88
JournalGenome biology
Volume6
Issue number10
StatePublished - 2005

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Cell Biology

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