Search for poliovirus carriers among people with primary immune deficiency diseases in the United States, Mexico, Brazil, and the United Kingdom

Neal A. Halsey, Jorge Pinto, Francisco Espinosa-Rosales, María A. Faure-Fontenla, Edson Da Silva, Aamir J. Khan, A. D.B. Webster, Philip Minor, Glynis Dunn, Edwin Asturias, Hamidah Hussain, Mark A. Pallansch, Olen M. Kew, Jerry Winkelstein, Roland Sutter, Claudete Araujo, Marluce Vilela, Cristina Jacob, Antonio Pastorino, Anete GrumachDewton Vasconcelos, Beatriz Carvalho, Virgínia Firriani, Nelson Rosario, Aluce Ouricuri, Norma Rubini, Roger H. Kobayashi, Craig M. Moffat, Mark A. Posner, Robert Albert Dracker, Alexander R. Lawton, A. Timothy Linehan, William R. Lumry

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To estimate the rate of long-term poliovirus excretors in people known to have B-cell immune deficiency disorders. Methods: An active search for chronic excretors was conducted among 306 persons known to have immunoglobulin G (IgG) deficiency in the United States, Mexico, Brazil, and the United Kingdom, and 40 people with IgA deficiency in the United States. Written informed consent or assent was obtained from the participants or their legal guardians, and the studies were formally approved. Stool samples were collected from participants and cultured for polioviruses. Calculation of the confidence interval for the proportion of participants with persistent poliovirus excretion was based on the binomial distribution. Findings: No individuals with long-term excretion of polioviruses were identified. Most participants had received oral poliovirus vaccine (OPV) and almost all had been exposed to household contacts who had received OPV. Polioviruses of recent vaccine origin were transiently found in four individuals in Mexico and Brazil, where OPV is recommended for all children. Conclusion: Although chronic poliovirus excretion can occur in immunodeficient persons, it appears to be rare.

Original languageEnglish (US)
Pages (from-to)3-8
Number of pages6
JournalBulletin of the World Health Organization
Volume82
Issue number1
StatePublished - Jan 2004

Keywords

  • Agammaglobulinemia
  • Brazil
  • Carrier state
  • Common variable immunodeficiency
  • IgA deficiency
  • IgG deficiency
  • Mexico
  • Poliomyelitis/chemically induced/transmission
  • Poliovirus vaccine, Oral/adverse effects
  • Poliovirus/isolation and purification
  • United States

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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