Abstract
Sea anemones produce a myriad of toxic peptides and proteins of which a large group acts on voltage-gated Na+ channels. However, in comparison to other organisms, their venoms and toxins are poorly studied. Most of the known voltage-gated Na+ channel toxins isolated from sea anemone venoms act on neurotoxin receptor site 3 and inhibit the inactivation of these channels. Furthermore, it seems that most of these toxins have a distinct preference for crustaceans. Given the close evolutionary relationship between crustaceans and insects, it is not surprising that sea anemone toxins also profoundly affect insect voltage-gated Na+ channels, which constitutes the scope of this review. For this reason, these peptides can be considered as insecticidal lead compounds in the development of insecticides.
Original language | English (US) |
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Pages (from-to) | 550-560 |
Number of pages | 11 |
Journal | Toxicon |
Volume | 49 |
Issue number | 4 |
DOIs | |
State | Published - Mar 15 2007 |
Externally published | Yes |
Keywords
- ATX-II
- Insecticide
- Sea anemone
- Site 3
- Toxin
- Voltage-gated sodium channel
ASJC Scopus subject areas
- Toxicology