Abstract
Sea anemones produce a myriad of toxic peptides and proteins of which a large group acts on voltage-gated Na+ channels. However, in comparison to other organisms, their venoms and toxins are poorly studied. Most of the known voltage-gated Na+ channel toxins isolated from sea anemone venoms act on neurotoxin receptor site 3 and inhibit the inactivation of these channels. Furthermore, it seems that most of these toxins have a distinct preference for crustaceans. Given the close evolutionary relationship between crustaceans and insects, it is not surprising that sea anemone toxins also profoundly affect insect voltage-gated Na+ channels, which constitutes the scope of this review. For this reason, these peptides can be considered as insecticidal lead compounds in the development of insecticides.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 550-560 |
| Number of pages | 11 |
| Journal | Toxicon |
| Volume | 49 |
| Issue number | 4 |
| DOIs | |
| State | Published - Mar 15 2007 |
| Externally published | Yes |
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Keywords
- ATX-II
- Insecticide
- Sea anemone
- Site 3
- Toxin
- Voltage-gated sodium channel
ASJC Scopus subject areas
- Toxicology
Cite this
Sea anemone venom as a source of insecticidal peptides acting on voltage-gated Na+ channels. / Bosmans, Frank; Tytgat, Jan.
In: Toxicon, Vol. 49, No. 4, 15.03.2007, p. 550-560.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Sea anemone venom as a source of insecticidal peptides acting on voltage-gated Na+ channels
AU - Bosmans, Frank
AU - Tytgat, Jan
PY - 2007/3/15
Y1 - 2007/3/15
N2 - Sea anemones produce a myriad of toxic peptides and proteins of which a large group acts on voltage-gated Na+ channels. However, in comparison to other organisms, their venoms and toxins are poorly studied. Most of the known voltage-gated Na+ channel toxins isolated from sea anemone venoms act on neurotoxin receptor site 3 and inhibit the inactivation of these channels. Furthermore, it seems that most of these toxins have a distinct preference for crustaceans. Given the close evolutionary relationship between crustaceans and insects, it is not surprising that sea anemone toxins also profoundly affect insect voltage-gated Na+ channels, which constitutes the scope of this review. For this reason, these peptides can be considered as insecticidal lead compounds in the development of insecticides.
AB - Sea anemones produce a myriad of toxic peptides and proteins of which a large group acts on voltage-gated Na+ channels. However, in comparison to other organisms, their venoms and toxins are poorly studied. Most of the known voltage-gated Na+ channel toxins isolated from sea anemone venoms act on neurotoxin receptor site 3 and inhibit the inactivation of these channels. Furthermore, it seems that most of these toxins have a distinct preference for crustaceans. Given the close evolutionary relationship between crustaceans and insects, it is not surprising that sea anemone toxins also profoundly affect insect voltage-gated Na+ channels, which constitutes the scope of this review. For this reason, these peptides can be considered as insecticidal lead compounds in the development of insecticides.
KW - ATX-II
KW - Insecticide
KW - Sea anemone
KW - Site 3
KW - Toxin
KW - Voltage-gated sodium channel
UR - http://www.scopus.com/inward/record.url?scp=33847411379&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33847411379&partnerID=8YFLogxK
U2 - 10.1016/j.toxicon.2006.11.029
DO - 10.1016/j.toxicon.2006.11.029
M3 - Article
C2 - 17224168
AN - SCOPUS:33847411379
VL - 49
SP - 550
EP - 560
JO - Toxicon
JF - Toxicon
SN - 0041-0101
IS - 4
ER -