Sea anemone venom as a source of insecticidal peptides acting on voltage-gated Na+ channels

Frank Bosmans, Jan Tytgat

Research output: Contribution to journalArticle

Abstract

Sea anemones produce a myriad of toxic peptides and proteins of which a large group acts on voltage-gated Na+ channels. However, in comparison to other organisms, their venoms and toxins are poorly studied. Most of the known voltage-gated Na+ channel toxins isolated from sea anemone venoms act on neurotoxin receptor site 3 and inhibit the inactivation of these channels. Furthermore, it seems that most of these toxins have a distinct preference for crustaceans. Given the close evolutionary relationship between crustaceans and insects, it is not surprising that sea anemone toxins also profoundly affect insect voltage-gated Na+ channels, which constitutes the scope of this review. For this reason, these peptides can be considered as insecticidal lead compounds in the development of insecticides.

Original languageEnglish (US)
Pages (from-to)550-560
Number of pages11
JournalToxicon
Volume49
Issue number4
DOIs
StatePublished - Mar 15 2007
Externally publishedYes

Fingerprint

Cnidarian Venoms
Sea Anemones
Insects
Peptides
Poisons
Venoms
Neurotoxins
Electric potential
Insecticides
Lead compounds
Proteins

Keywords

  • ATX-II
  • Insecticide
  • Sea anemone
  • Site 3
  • Toxin
  • Voltage-gated sodium channel

ASJC Scopus subject areas

  • Toxicology

Cite this

Sea anemone venom as a source of insecticidal peptides acting on voltage-gated Na+ channels. / Bosmans, Frank; Tytgat, Jan.

In: Toxicon, Vol. 49, No. 4, 15.03.2007, p. 550-560.

Research output: Contribution to journalArticle

Bosmans, Frank ; Tytgat, Jan. / Sea anemone venom as a source of insecticidal peptides acting on voltage-gated Na+ channels. In: Toxicon. 2007 ; Vol. 49, No. 4. pp. 550-560.
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