Screening of CEST MR contrast agents

Xiaolei Song, Kannie W Y Chan, Michael T Mcmahon

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

There has been a tremendous amount of interest in developing new MR contrast agents for cellular and molecular imaging applications such as the visualization of tumors, highlighting areas of angiogenesis, highlighting of contrast agent-labeled therapeutic stem cells, and highlighting of contrast agent-labeled drug delivery vehicles. The contrast properties of paramagnetic and super-paramagnetic relaxation-based agents have allowed MR imaging to be used as a tool for all of the above applications. However, a new class of MR contrast agents, chemical exchange saturation transfer (CEST) agents, provides additional features such as (1) the ability to highlight multiple biological events at once within an image through the distinguishability of the different CEST contrast agents, (2) the ability to toggle the contrast "off-to-on" by applying a saturation pulse, and (3) potentially providing more information about the environment surrounding the contrast agent such as the pH or concentration of metabolites. In this chapter, we will focus on the methods which can be used in terms of acquisition schemes and hardware to screen these agents through MR imaging.

Original languageEnglish (US)
Title of host publicationMethods in Molecular Biology
Pages171-187
Number of pages17
Volume771
DOIs
StatePublished - 2011

Publication series

NameMethods in Molecular Biology
Volume771
ISSN (Print)10643745

Fingerprint

Contrast Media
Molecular Imaging
Stem Cells
Pharmaceutical Preparations
Neoplasms

Keywords

  • CEST
  • contrast agents
  • molecular imaging
  • MRI

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics

Cite this

Song, X., Chan, K. W. Y., & Mcmahon, M. T. (2011). Screening of CEST MR contrast agents. In Methods in Molecular Biology (Vol. 771, pp. 171-187). (Methods in Molecular Biology; Vol. 771). https://doi.org/10.1007/978-1-61779-219-9_9

Screening of CEST MR contrast agents. / Song, Xiaolei; Chan, Kannie W Y; Mcmahon, Michael T.

Methods in Molecular Biology. Vol. 771 2011. p. 171-187 (Methods in Molecular Biology; Vol. 771).

Research output: Chapter in Book/Report/Conference proceedingChapter

Song, X, Chan, KWY & Mcmahon, MT 2011, Screening of CEST MR contrast agents. in Methods in Molecular Biology. vol. 771, Methods in Molecular Biology, vol. 771, pp. 171-187. https://doi.org/10.1007/978-1-61779-219-9_9
Song X, Chan KWY, Mcmahon MT. Screening of CEST MR contrast agents. In Methods in Molecular Biology. Vol. 771. 2011. p. 171-187. (Methods in Molecular Biology). https://doi.org/10.1007/978-1-61779-219-9_9
Song, Xiaolei ; Chan, Kannie W Y ; Mcmahon, Michael T. / Screening of CEST MR contrast agents. Methods in Molecular Biology. Vol. 771 2011. pp. 171-187 (Methods in Molecular Biology).
@inbook{2670347615554fc4a1aeb08ec05caa12,
title = "Screening of CEST MR contrast agents",
abstract = "There has been a tremendous amount of interest in developing new MR contrast agents for cellular and molecular imaging applications such as the visualization of tumors, highlighting areas of angiogenesis, highlighting of contrast agent-labeled therapeutic stem cells, and highlighting of contrast agent-labeled drug delivery vehicles. The contrast properties of paramagnetic and super-paramagnetic relaxation-based agents have allowed MR imaging to be used as a tool for all of the above applications. However, a new class of MR contrast agents, chemical exchange saturation transfer (CEST) agents, provides additional features such as (1) the ability to highlight multiple biological events at once within an image through the distinguishability of the different CEST contrast agents, (2) the ability to toggle the contrast {"}off-to-on{"} by applying a saturation pulse, and (3) potentially providing more information about the environment surrounding the contrast agent such as the pH or concentration of metabolites. In this chapter, we will focus on the methods which can be used in terms of acquisition schemes and hardware to screen these agents through MR imaging.",
keywords = "CEST, contrast agents, molecular imaging, MRI",
author = "Xiaolei Song and Chan, {Kannie W Y} and Mcmahon, {Michael T}",
year = "2011",
doi = "10.1007/978-1-61779-219-9_9",
language = "English (US)",
isbn = "9781617792182",
volume = "771",
series = "Methods in Molecular Biology",
pages = "171--187",
booktitle = "Methods in Molecular Biology",

}

TY - CHAP

T1 - Screening of CEST MR contrast agents

AU - Song, Xiaolei

AU - Chan, Kannie W Y

AU - Mcmahon, Michael T

PY - 2011

Y1 - 2011

N2 - There has been a tremendous amount of interest in developing new MR contrast agents for cellular and molecular imaging applications such as the visualization of tumors, highlighting areas of angiogenesis, highlighting of contrast agent-labeled therapeutic stem cells, and highlighting of contrast agent-labeled drug delivery vehicles. The contrast properties of paramagnetic and super-paramagnetic relaxation-based agents have allowed MR imaging to be used as a tool for all of the above applications. However, a new class of MR contrast agents, chemical exchange saturation transfer (CEST) agents, provides additional features such as (1) the ability to highlight multiple biological events at once within an image through the distinguishability of the different CEST contrast agents, (2) the ability to toggle the contrast "off-to-on" by applying a saturation pulse, and (3) potentially providing more information about the environment surrounding the contrast agent such as the pH or concentration of metabolites. In this chapter, we will focus on the methods which can be used in terms of acquisition schemes and hardware to screen these agents through MR imaging.

AB - There has been a tremendous amount of interest in developing new MR contrast agents for cellular and molecular imaging applications such as the visualization of tumors, highlighting areas of angiogenesis, highlighting of contrast agent-labeled therapeutic stem cells, and highlighting of contrast agent-labeled drug delivery vehicles. The contrast properties of paramagnetic and super-paramagnetic relaxation-based agents have allowed MR imaging to be used as a tool for all of the above applications. However, a new class of MR contrast agents, chemical exchange saturation transfer (CEST) agents, provides additional features such as (1) the ability to highlight multiple biological events at once within an image through the distinguishability of the different CEST contrast agents, (2) the ability to toggle the contrast "off-to-on" by applying a saturation pulse, and (3) potentially providing more information about the environment surrounding the contrast agent such as the pH or concentration of metabolites. In this chapter, we will focus on the methods which can be used in terms of acquisition schemes and hardware to screen these agents through MR imaging.

KW - CEST

KW - contrast agents

KW - molecular imaging

KW - MRI

UR - http://www.scopus.com/inward/record.url?scp=80054778628&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=80054778628&partnerID=8YFLogxK

U2 - 10.1007/978-1-61779-219-9_9

DO - 10.1007/978-1-61779-219-9_9

M3 - Chapter

C2 - 21874478

AN - SCOPUS:80054778628

SN - 9781617792182

VL - 771

T3 - Methods in Molecular Biology

SP - 171

EP - 187

BT - Methods in Molecular Biology

ER -