TY - JOUR
T1 - Screening for vision-threatening diabetic retinopathy in South India
T2 - Comparing portable non-mydriatic and standard fundus cameras and clinical exam
AU - Sengupta, S.
AU - Sindal, M. D.
AU - Besirli, C. G.
AU - Upadhyaya, S.
AU - Venkatesh, R.
AU - Niziol, L. M.
AU - Robin, A. L.
AU - Woodward, M. A.
AU - Newman-Casey, P. A.
N1 - Funding Information:
We would like to acknowledge the critical contributions of Saravanan Sathish (ophthalmic photographer from Aravind Eye Hospital, Pondicherry, India), Alexis Cullen, BA (ophthalmic photographer from the University of Michigan, Ann Arbor, Michigan) and Chris Andrews, PhD (Statistical consultation from the University of Michigan, Ann Arbor, Michigan) to this work. This work was supported by the Michigan Vision Clinician-Scientist Development Program K12EY022299 (PANC). The funding organization had no role in the design or conduct of this research. The manuscript has been presented, in part, as a poster presentation at the annual meeting of the Association for Research in Vision and Ophthalmology in Denver, Colorado, 4 May, 2015.
PY - 2018/2/1
Y1 - 2018/2/1
N2 - PurposeTo evaluate the sensitivity and specificity of a portable non-mydriatic fundus camera to diagnose vision-threatening diabetic retinopathy (VTDR).Patients and methodsA prospective, single-site, comparative instrument validation study was undertaken at the Aravind Eye Care System. Overall, 155 subjects with and without diabetes were recruited. Images from 275 eyes were obtained with the (1) non-mydriatic Smartscope, (2) mydriatic Smartscope, and (3) mydriatic table-top camera of the macular, nasal, and superotemporal fields. A retina specialist performed a dilated fundus examination (DFE), (reference standard). Two masked retina specialists graded the images. Sensitivity and specificity to detect VTDR with the undilated Smartscope was calculated compared to DFE.ResultsGraders 1 and 2 had a sensitivity of 93% (95% confidence interval (CI): 87-97%) and 88% (95% CI: 81-93%) and a specificity of 84% (95% CI: 77-89%) and 90% (95% CI: 84-94%), respectively, in diagnosing VTDR with the undilated Smartscope compared to DFE. Compared with the dilated Topcon images, graders 1 and 2 had sensitivity of 88% (95% CI: 81-93%) and 82% (95% CI: 73-88%) and specificity of 99% (95% CI: 96-100%) and 99% (95% CI: 95-100%).ConclusionsRemote graders had high sensitivity and specificity in diagnosing VTDR with undilated Smartscope images, suggesting utility where portability is a necessity.
AB - PurposeTo evaluate the sensitivity and specificity of a portable non-mydriatic fundus camera to diagnose vision-threatening diabetic retinopathy (VTDR).Patients and methodsA prospective, single-site, comparative instrument validation study was undertaken at the Aravind Eye Care System. Overall, 155 subjects with and without diabetes were recruited. Images from 275 eyes were obtained with the (1) non-mydriatic Smartscope, (2) mydriatic Smartscope, and (3) mydriatic table-top camera of the macular, nasal, and superotemporal fields. A retina specialist performed a dilated fundus examination (DFE), (reference standard). Two masked retina specialists graded the images. Sensitivity and specificity to detect VTDR with the undilated Smartscope was calculated compared to DFE.ResultsGraders 1 and 2 had a sensitivity of 93% (95% confidence interval (CI): 87-97%) and 88% (95% CI: 81-93%) and a specificity of 84% (95% CI: 77-89%) and 90% (95% CI: 84-94%), respectively, in diagnosing VTDR with the undilated Smartscope compared to DFE. Compared with the dilated Topcon images, graders 1 and 2 had sensitivity of 88% (95% CI: 81-93%) and 82% (95% CI: 73-88%) and specificity of 99% (95% CI: 96-100%) and 99% (95% CI: 95-100%).ConclusionsRemote graders had high sensitivity and specificity in diagnosing VTDR with undilated Smartscope images, suggesting utility where portability is a necessity.
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U2 - 10.1038/eye.2017.199
DO - 10.1038/eye.2017.199
M3 - Article
C2 - 28912515
AN - SCOPUS:85041806824
SN - 0950-222X
VL - 32
SP - 375
EP - 383
JO - Transactions of the Ophthalmological Societies of the United Kingdom
JF - Transactions of the Ophthalmological Societies of the United Kingdom
IS - 2
ER -