Screening for Pancreatic Cancer

Saowanee Ngamruengphong; Marcia Irene Canto

doi:10.1016/j.suc.2016.07.016

Screening for Pancreatic Cancer

Saowanee Ngamruengphong, Marcia Irene Canto

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Pancreatic cancer (PC) is a highly fatal disease that can only be cured by complete surgical resection. However, most patients with PC have unresectable disease at the time of diagnosis, highlighting the need to detect PC and its precursor lesions earlier in asymptomatic patients. Screening is not cost-effective for population-based screening of PC. Individuals with genetic risk factors for PC based on family history or known PC-associated genetic syndromes, however, can be a potential target for PC screening programs. This article provides an overview of the epidemiology and genetic background of familial PC and discusses diagnostic and management approaches.

Original language	English (US)
Pages (from-to)	1223-1233
Number of pages	11
Journal	Surgical Clinics of North America
Volume	96
Issue number	6
DOIs	https://doi.org/10.1016/j.suc.2016.07.016
State	Published - Dec 1 2016

Keywords

Familial pancreatic cancer
Intraductal papillary mucinous neoplasm
Pancreatic cancer
Pancreatic cyst
Pancreatic intraepithelial neoplasia
Screening

ASJC Scopus subject areas

Surgery

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10.1016/j.suc.2016.07.016

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title = "Screening for Pancreatic Cancer",

abstract = "Pancreatic cancer (PC) is a highly fatal disease that can only be cured by complete surgical resection. However, most patients with PC have unresectable disease at the time of diagnosis, highlighting the need to detect PC and its precursor lesions earlier in asymptomatic patients. Screening is not cost-effective for population-based screening of PC. Individuals with genetic risk factors for PC based on family history or known PC-associated genetic syndromes, however, can be a potential target for PC screening programs. This article provides an overview of the epidemiology and genetic background of familial PC and discusses diagnostic and management approaches.",

keywords = "Familial pancreatic cancer, Intraductal papillary mucinous neoplasm, Pancreatic cancer, Pancreatic cyst, Pancreatic intraepithelial neoplasia, Screening",

author = "Saowanee Ngamruengphong and Canto, {Marcia Irene}",

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AU - Ngamruengphong, Saowanee

AU - Canto, Marcia Irene

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AB - Pancreatic cancer (PC) is a highly fatal disease that can only be cured by complete surgical resection. However, most patients with PC have unresectable disease at the time of diagnosis, highlighting the need to detect PC and its precursor lesions earlier in asymptomatic patients. Screening is not cost-effective for population-based screening of PC. Individuals with genetic risk factors for PC based on family history or known PC-associated genetic syndromes, however, can be a potential target for PC screening programs. This article provides an overview of the epidemiology and genetic background of familial PC and discusses diagnostic and management approaches.

KW - Familial pancreatic cancer

KW - Intraductal papillary mucinous neoplasm

KW - Pancreatic cancer

KW - Pancreatic cyst

KW - Pancreatic intraepithelial neoplasia

KW - Screening

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