TY - JOUR
T1 - Screening for Pancreatic Cancer
AU - Ngamruengphong, Saowanee
AU - Canto, Marcia Irene
N1 - Publisher Copyright:
© 2016 Elsevier Inc.
Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Pancreatic cancer (PC) is a highly fatal disease that can only be cured by complete surgical resection. However, most patients with PC have unresectable disease at the time of diagnosis, highlighting the need to detect PC and its precursor lesions earlier in asymptomatic patients. Screening is not cost-effective for population-based screening of PC. Individuals with genetic risk factors for PC based on family history or known PC-associated genetic syndromes, however, can be a potential target for PC screening programs. This article provides an overview of the epidemiology and genetic background of familial PC and discusses diagnostic and management approaches.
AB - Pancreatic cancer (PC) is a highly fatal disease that can only be cured by complete surgical resection. However, most patients with PC have unresectable disease at the time of diagnosis, highlighting the need to detect PC and its precursor lesions earlier in asymptomatic patients. Screening is not cost-effective for population-based screening of PC. Individuals with genetic risk factors for PC based on family history or known PC-associated genetic syndromes, however, can be a potential target for PC screening programs. This article provides an overview of the epidemiology and genetic background of familial PC and discusses diagnostic and management approaches.
KW - Familial pancreatic cancer
KW - Intraductal papillary mucinous neoplasm
KW - Pancreatic cancer
KW - Pancreatic cyst
KW - Pancreatic intraepithelial neoplasia
KW - Screening
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U2 - 10.1016/j.suc.2016.07.016
DO - 10.1016/j.suc.2016.07.016
M3 - Review article
C2 - 27865274
AN - SCOPUS:84996523363
VL - 96
SP - 1223
EP - 1233
JO - Surgical Clinics of North America
JF - Surgical Clinics of North America
SN - 0039-6109
IS - 6
ER -