Screening for familial and hereditary prostate cancer

Henry T. Lynch, Omofolasade Kosoko-Lasaki, Stephen W. Leslie, Marc Rendell, Trudy Shaw, Carrie Snyder, Anthony V. D'Amico, Sarah Buxbaum, William B Isaacs, Stacy Loeb, Judd W. Moul, Isaac Powell

Research output: Contribution to journalArticle

Abstract

Prostate cancer (PC) has the highest degree of genetic transmission of any form of malignancy. In some families, the hereditary pattern is so strong as to mimic an autosomal dominance trait. We reviewed the known predisposing genetic markers to assess possible strategies for screening of families at risk. We carried out a systematic literature search using the Pubmed service of the National Center for Biotechnology Information (NCBI) and several gene libraries, including the NCBI SNP Library, the Online Mendelian Inheritance in Man® Catalog of Human Genes and Genetic Disorders (OMIM) and SNPedia to obtain known gene loci, SNPs and satellite markers associated with PC. We further cross referenced information on identified loci comparing data from different articles and gene reference sites. Whenever possible, we recorded the odds ratio (OR) for the allele associated with PC. In multiple different linkage studies, many independent PC associated loci have been identified on separate chromosomes. Genome-wide association studies have added many more markers to the set derived from linkage investigations. A subset of the alleles is associated with early onset and aggressive cancer. Due to the great heterogeneity, the OR for any one allele predicting future development of this malignancy is low. The strongest predictors are the BRCA2 mutations, and the highly penetrant G84E mutation in HOXB13. The presence of multiple risk alleles is more highly predictive than a single allele. Technical limitations on screening large panels of alleles are being overcome. It is appropriate to begin supplementing prostate specific antigen testing with alleles, such as BRCA2 and HOXB13, disclosed by targeted genomic analysis in families with an unfavorable family cancer history. Future population studies of PC should include genomic sequencing protocols, particularly in families with a history of PC and other malignancies.

Original languageEnglish (US)
Pages (from-to)2579-2591
Number of pages13
JournalInternational Journal of Cancer
Volume138
Issue number11
DOIs
StatePublished - Jun 1 2016

Fingerprint

Alleles
Prostatic Neoplasms
Genetic Databases
Information Centers
Neoplasms
Biotechnology
Single Nucleotide Polymorphism
Odds Ratio
Genes
Mutation
Inborn Genetic Diseases
Genome-Wide Association Study
Medical Genetics
Prostate-Specific Antigen
Familial Prostate cancer
Gene Library
Genetic Markers
PubMed
Libraries
Chromosomes

Keywords

  • BRCA2
  • genome wide association studies
  • HOXB13
  • prostate cancer
  • prostate specific antigen

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Lynch, H. T., Kosoko-Lasaki, O., Leslie, S. W., Rendell, M., Shaw, T., Snyder, C., ... Powell, I. (2016). Screening for familial and hereditary prostate cancer. International Journal of Cancer, 138(11), 2579-2591. https://doi.org/10.1002/ijc.29949

Screening for familial and hereditary prostate cancer. / Lynch, Henry T.; Kosoko-Lasaki, Omofolasade; Leslie, Stephen W.; Rendell, Marc; Shaw, Trudy; Snyder, Carrie; D'Amico, Anthony V.; Buxbaum, Sarah; Isaacs, William B; Loeb, Stacy; Moul, Judd W.; Powell, Isaac.

In: International Journal of Cancer, Vol. 138, No. 11, 01.06.2016, p. 2579-2591.

Research output: Contribution to journalArticle

Lynch, HT, Kosoko-Lasaki, O, Leslie, SW, Rendell, M, Shaw, T, Snyder, C, D'Amico, AV, Buxbaum, S, Isaacs, WB, Loeb, S, Moul, JW & Powell, I 2016, 'Screening for familial and hereditary prostate cancer', International Journal of Cancer, vol. 138, no. 11, pp. 2579-2591. https://doi.org/10.1002/ijc.29949
Lynch HT, Kosoko-Lasaki O, Leslie SW, Rendell M, Shaw T, Snyder C et al. Screening for familial and hereditary prostate cancer. International Journal of Cancer. 2016 Jun 1;138(11):2579-2591. https://doi.org/10.1002/ijc.29949
Lynch, Henry T. ; Kosoko-Lasaki, Omofolasade ; Leslie, Stephen W. ; Rendell, Marc ; Shaw, Trudy ; Snyder, Carrie ; D'Amico, Anthony V. ; Buxbaum, Sarah ; Isaacs, William B ; Loeb, Stacy ; Moul, Judd W. ; Powell, Isaac. / Screening for familial and hereditary prostate cancer. In: International Journal of Cancer. 2016 ; Vol. 138, No. 11. pp. 2579-2591.
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