Abstract
Clonality is a fundamental characteristic of all human cancers. One cancer cell gives rise to daughter cells, all of which exhibit the same change that initially provided a growth advantage to the parent cell. Accumulation of further genetic changes in subsequent daughter cells, each provicling an additional growth advantage, has been well documented in human cancer. Correlation of these clonal genetic changes with histopathological progression has led to development of a molecular progression model for colorectal cancer. The identification of genetic markers able to identify the clonal outgrowth of neoplastic cells has proven useful in the detection of a variety of primary neoplasms.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1127-1129 |
| Number of pages | 3 |
| Journal | European Journal of Cancer |
| Volume | 31 |
| Issue number | 7-8 |
| DOIs | |
| State | Published - 1995 |
| Externally published | Yes |
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Keywords
- cancer detection
- genetic alterations
- molecular screening
ASJC Scopus subject areas
- Cancer Research
- Oncology
- Hematology
Cite this
Screening for clonal genetic alterations. / Sidransky, David.
In: European Journal of Cancer, Vol. 31, No. 7-8, 1995, p. 1127-1129.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Screening for clonal genetic alterations
AU - Sidransky, David
PY - 1995
Y1 - 1995
N2 - Clonality is a fundamental characteristic of all human cancers. One cancer cell gives rise to daughter cells, all of which exhibit the same change that initially provided a growth advantage to the parent cell. Accumulation of further genetic changes in subsequent daughter cells, each provicling an additional growth advantage, has been well documented in human cancer. Correlation of these clonal genetic changes with histopathological progression has led to development of a molecular progression model for colorectal cancer. The identification of genetic markers able to identify the clonal outgrowth of neoplastic cells has proven useful in the detection of a variety of primary neoplasms.
AB - Clonality is a fundamental characteristic of all human cancers. One cancer cell gives rise to daughter cells, all of which exhibit the same change that initially provided a growth advantage to the parent cell. Accumulation of further genetic changes in subsequent daughter cells, each provicling an additional growth advantage, has been well documented in human cancer. Correlation of these clonal genetic changes with histopathological progression has led to development of a molecular progression model for colorectal cancer. The identification of genetic markers able to identify the clonal outgrowth of neoplastic cells has proven useful in the detection of a variety of primary neoplasms.
KW - cancer detection
KW - genetic alterations
KW - molecular screening
UR - http://www.scopus.com/inward/record.url?scp=0029091177&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029091177&partnerID=8YFLogxK
U2 - 10.1016/0959-8049(95)00167-H
DO - 10.1016/0959-8049(95)00167-H
M3 - Article
C2 - 7577006
AN - SCOPUS:0029091177
VL - 31
SP - 1127
EP - 1129
JO - European Journal of Cancer
JF - European Journal of Cancer
SN - 0959-8049
IS - 7-8
ER -