Screening for clonal genetic alterations

Research output: Contribution to journalArticle

Abstract

Clonality is a fundamental characteristic of all human cancers. One cancer cell gives rise to daughter cells, all of which exhibit the same change that initially provided a growth advantage to the parent cell. Accumulation of further genetic changes in subsequent daughter cells, each provicling an additional growth advantage, has been well documented in human cancer. Correlation of these clonal genetic changes with histopathological progression has led to development of a molecular progression model for colorectal cancer. The identification of genetic markers able to identify the clonal outgrowth of neoplastic cells has proven useful in the detection of a variety of primary neoplasms.

Original languageEnglish (US)
Pages (from-to)1127-1129
Number of pages3
JournalEuropean Journal of Cancer
Volume31
Issue number7-8
DOIs
StatePublished - 1995
Externally publishedYes

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Genetic Testing
Neoplasms
Molecular Models
Growth
Genetic Markers
Colorectal Neoplasms

Keywords

  • cancer detection
  • genetic alterations
  • molecular screening

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Hematology

Cite this

Screening for clonal genetic alterations. / Sidransky, David.

In: European Journal of Cancer, Vol. 31, No. 7-8, 1995, p. 1127-1129.

Research output: Contribution to journalArticle

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