Screening for cerebral palsy in preterm infants

delay criteria for motor milestone attainment.

Marilee C Allen, G. R. Alexander

Research output: Contribution to journalArticle

Abstract

We evaluated the efficacy of various delay criteria (12.5%, 25%, 37.5%, 5%, 50% delay) for motor milestone attainment to screen a sample of 173 high-risk preterm infants with gestational age <32 weeks who had been sequentially followed for 18 to 24 months. Sensitivities were best with 12.5% and 25% delays, but specificities and positive predictive values were relatively lower. Since societal resources for evaluation and treatment of cerebral palsy are limited, the excellent specificities (81% to 95%) and positive predictive values (48% to 85%) with 50% delay are more important than the somewhat lower sensitivities, especially since milestones involve a multistep screening process. Screening preterm infants by obtaining a history of motor milestone attainment with each child care visit, correcting for degree of prematurity, and using a 50% delay criteria is a practical, inexpensive method of identifying infants at highest risk of cerebral palsy.

Original languageEnglish (US)
Pages (from-to)190-193
Number of pages4
JournalJournal of perinatology : official journal of the California Perinatal Association
Volume14
Issue number3
StatePublished - May 1994

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Cerebral Palsy
Premature Infants
Child Care
Gestational Age
Therapeutics

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pediatrics, Perinatology, and Child Health

Cite this

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title = "Screening for cerebral palsy in preterm infants: delay criteria for motor milestone attainment.",
abstract = "We evaluated the efficacy of various delay criteria (12.5{\%}, 25{\%}, 37.5{\%}, 5{\%}, 50{\%} delay) for motor milestone attainment to screen a sample of 173 high-risk preterm infants with gestational age <32 weeks who had been sequentially followed for 18 to 24 months. Sensitivities were best with 12.5{\%} and 25{\%} delays, but specificities and positive predictive values were relatively lower. Since societal resources for evaluation and treatment of cerebral palsy are limited, the excellent specificities (81{\%} to 95{\%}) and positive predictive values (48{\%} to 85{\%}) with 50{\%} delay are more important than the somewhat lower sensitivities, especially since milestones involve a multistep screening process. Screening preterm infants by obtaining a history of motor milestone attainment with each child care visit, correcting for degree of prematurity, and using a 50{\%} delay criteria is a practical, inexpensive method of identifying infants at highest risk of cerebral palsy.",
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