Screening CEST contrast agents using ultrafast CEST imaging

Xiang Xu, Nirbhay N. Yadav, Xiaolei Song, Michael T. McMahon, Alexej Jerschow, Peter C.M. Van Zijl, Jiadi Xu

Research output: Contribution to journalArticle

Abstract

A chemical exchange saturation transfer (CEST) experiment can be performed in an ultrafast fashion if a gradient field is applied simultaneously with the saturation pulse. This approach has been demonstrated for studying dia- and para-magnetic CEST agents, hyperpolarized Xe gas and in vivo spectroscopy. In this study we present a simple method for the simultaneous screening of multiple samples. Furthermore, by interleaving a number of saturation and readout periods within the TR, a series of images with different saturation times can be acquired, allowing for the quantification of exchange rates using the variable saturation time (QUEST) approach in a much accelerated fashion, thus enabling high throughput screening of CEST contrast agents.

Original languageEnglish (US)
Pages (from-to)224-229
Number of pages6
JournalJournal of Magnetic Resonance
Volume265
DOIs
StatePublished - Apr 1 2016

Keywords

  • CEST
  • Contrast agent
  • MRI
  • Ultrafast spectroscopy

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Nuclear and High Energy Physics
  • Condensed Matter Physics

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