Scopolamine effects on the pressor response to thyrotropin-releasing hormone in humans

Susan E. Molchan; James L. Hill; Marcia Minichiello; Benedetto Vitiello; Trey Sunderland

doi:10.1016/0024-3205(94)00629-6

Scopolamine effects on the pressor response to thyrotropin-releasing hormone in humans

Susan E. Molchan, James L. Hill, Marcia Minichiello, Benedetto Vitiello, Trey Sunderland

Suburban Hospital

Research output: Contribution to journal › Article › peer-review

Abstract

Thyrotropin-releasing hormone (TRH) produces a marked pressor effect, which may be mediated by central cholinergic neurons, which in turn enhance sympathetic nervous system activity. In this study, 22 subjects (10 patients with Alzheimer's disease and 12 elderly controls) were administered IV scopolamine or placebo prior to administration of IV high-dose TRH (0.5 mg/kg). Systolic blood pressure was less on the day scopolamine was administered prior to TRH administration, as compared with placebo (F[1,20]=6.12, p<0.02). Results indicate that the pressor effect of TRH is attenuated by scopolamine, indicating a role of the cholinergic system in this response in humans.

Original language	English (US)
Pages (from-to)	933-938
Number of pages	6
Journal	Life Sciences
Volume	54
Issue number	13
DOIs	https://doi.org/10.1016/0024-3205(94)00629-6
State	Published - 1994

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/0024-3205(94)00629-6

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title = "Scopolamine effects on the pressor response to thyrotropin-releasing hormone in humans",

abstract = "Thyrotropin-releasing hormone (TRH) produces a marked pressor effect, which may be mediated by central cholinergic neurons, which in turn enhance sympathetic nervous system activity. In this study, 22 subjects (10 patients with Alzheimer's disease and 12 elderly controls) were administered IV scopolamine or placebo prior to administration of IV high-dose TRH (0.5 mg/kg). Systolic blood pressure was less on the day scopolamine was administered prior to TRH administration, as compared with placebo (F[1,20]=6.12, p<0.02). Results indicate that the pressor effect of TRH is attenuated by scopolamine, indicating a role of the cholinergic system in this response in humans.",

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T1 - Scopolamine effects on the pressor response to thyrotropin-releasing hormone in humans

AU - Molchan, Susan E.

AU - Hill, James L.

AU - Minichiello, Marcia

AU - Vitiello, Benedetto

AU - Sunderland, Trey

PY - 1994

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N2 - Thyrotropin-releasing hormone (TRH) produces a marked pressor effect, which may be mediated by central cholinergic neurons, which in turn enhance sympathetic nervous system activity. In this study, 22 subjects (10 patients with Alzheimer's disease and 12 elderly controls) were administered IV scopolamine or placebo prior to administration of IV high-dose TRH (0.5 mg/kg). Systolic blood pressure was less on the day scopolamine was administered prior to TRH administration, as compared with placebo (F[1,20]=6.12, p<0.02). Results indicate that the pressor effect of TRH is attenuated by scopolamine, indicating a role of the cholinergic system in this response in humans.

AB - Thyrotropin-releasing hormone (TRH) produces a marked pressor effect, which may be mediated by central cholinergic neurons, which in turn enhance sympathetic nervous system activity. In this study, 22 subjects (10 patients with Alzheimer's disease and 12 elderly controls) were administered IV scopolamine or placebo prior to administration of IV high-dose TRH (0.5 mg/kg). Systolic blood pressure was less on the day scopolamine was administered prior to TRH administration, as compared with placebo (F[1,20]=6.12, p<0.02). Results indicate that the pressor effect of TRH is attenuated by scopolamine, indicating a role of the cholinergic system in this response in humans.

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Scopolamine effects on the pressor response to thyrotropin-releasing hormone in humans

Abstract

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