Sclerosing cholangitis and histiocytosis X

H. H. Thompson, H. A. Pitt, K. J. Lewin, W. P. Longmire

Research output: Contribution to journalArticle

Abstract

Three patients with biopsy proven histiocytosis X who developed a clinical and pathological picture compatible with sclerosing cholangitis are reported. In one patient, operative biopsy of the common bile duct revealed histiocytosis X in the granulomatous/xanthomatous phase. At necrospy, however, only fibrosis of the biliary tree was seen, a picture consistent with sclerosing cholangitis. Fibrotic obstruction of the biliary tree led to death from liver failure in all three patients. The aetiology of primary sclerosing cholangitis is unknown and may be multifactorial. Perhaps involvement of the biliary tree by histiocytosis X is one cause.

Original languageEnglish (US)
Pages (from-to)526-530
Number of pages5
JournalGut
Volume25
Issue number5
DOIs
StatePublished - Jan 1 1984

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ASJC Scopus subject areas

  • Gastroenterology

Cite this

Thompson, H. H., Pitt, H. A., Lewin, K. J., & Longmire, W. P. (1984). Sclerosing cholangitis and histiocytosis X. Gut, 25(5), 526-530. https://doi.org/10.1136/gut.25.5.526