Science to practice: The changing face of local tumor therapies - Do we have to think systemically when treating cancer locally?

Julius Chapiro, Jean François Geschwind

Research output: Contribution to journalArticle


In this issue, Rozenblum et al (1) were able to demonstrate that radiofrequency (RF) ablation-induced liver regeneration promotes "off-target" tumorigenesis in a MDR2 knock-out mouse model of hepatocellular carcinoma (HCC) in the setting of chronic liver inflammation. In addition, the authors demonstrated that blocking liver regeneration with a c-met inhibitor might attenuate or eliminate potential tumorigenic effects. These results provide the rationale for combined therapeutic approaches of RF ablation followed by a systemic application of immunomodulatory drugs.

Original languageEnglish (US)
Pages (from-to)315-317
Number of pages3
Issue number2
Publication statusPublished - Aug 1 2015
Externally publishedYes


ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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