Science to practice: Can MR imaging cell tracking of macrophage infiltration be used as a predictive imaging biomarker for transplanted stem cell rejection?

Research output: Contribution to journalArticle

Abstract

Ferumoxytol-enhanced magnetic resonance (MR) imaging of donor-matched and mismatched stem cell transplants demonstrated decreased signal intensity not only for a xenogeneic mismatch in species but, surprisingly, also for a syngeneic mismatch in sex. MR imaging findings were corroborated with intravital fluorescence microscopy (IVM), where nearly 90% of all ferumoxytol-containing cells were found to be macrophages. Hence, MR imaging cell tracking of infiltrating macrophages may have predictive value in determining whether transplanted stem cell rejection will occur.

Original languageEnglish (US)
Pages (from-to)307-309
Number of pages3
JournalRadiology
Volume284
Issue number2
DOIs
StatePublished - Aug 1 2017

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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