Science to Practice: Can Decreased Lymph Node MR Imaging Signal Intensity Be Used as a Biomarker for the Efficacy of Cancer Vaccination?

Jeff W.M. Bulte

doi:10.1148/radiol.14142331

Science to Practice: Can Decreased Lymph Node MR Imaging Signal Intensity Be Used as a Biomarker for the Efficacy of Cancer Vaccination?

Jeff W.M. Bulte

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

In the study of Zhang et al (1), tumor-bearing mice were vaccinated with magnetically labeled, tumor antigen-primed dendritic cells (DCs). After homing of these antigen-presenting cells to the draining lymph node (LN), it was shown that the iron oxide-induced decrease in LN magnetic resonance (MR) imaging signal intensity correlated with the observed tumor growth delay, suggesting that the degree of hypointensity can serve as a surrogate marker for the efficacy of tumor vaccination.

Original language	English (US)
Pages (from-to)	1-3
Number of pages	3
Journal	RADIOLOGY
Volume	274
Issue number	1
DOIs	https://doi.org/10.1148/radiol.14142331
State	Published - Jan 1 2015

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging

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10.1148/radiol.14142331

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Science to Practice: Can Decreased Lymph Node MR Imaging Signal Intensity Be Used as a Biomarker for the Efficacy of Cancer Vaccination?

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