Science to Practice: Can Decreased Lymph Node MR Imaging Signal Intensity Be Used as a Biomarker for the Efficacy of Cancer Vaccination?

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In the study of Zhang et al (1), tumor-bearing mice were vaccinated with magnetically labeled, tumor antigen-primed dendritic cells (DCs). After homing of these antigen-presenting cells to the draining lymph node (LN), it was shown that the iron oxide-induced decrease in LN magnetic resonance (MR) imaging signal intensity correlated with the observed tumor growth delay, suggesting that the degree of hypointensity can serve as a surrogate marker for the efficacy of tumor vaccination.

Original languageEnglish (US)
Pages (from-to)1-3
Number of pages3
Issue number1
Publication statusPublished - Jan 1 2015


ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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