Science signaling podcast: 12 February 2013

Gregg L. Semenza; Maimon E. Hubbi; Annalisa M. VanHook

doi:10.1126/scisignal.2004007

Science signaling podcast: 12 February 2013

Gregg L. Semenza, Maimon E. Hubbi, Annalisa M. VanHook

School of Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

This Podcast features an interview Gregg Semenza and Maimon Hubbi, authors of a paper that appears in the 12 February 2013 issue of Science Signaling. Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric protein that mediates the transcriptional response to hypoxia, the decreased availability of oxygen. One of the outcomes of HIF-1α mediated gene regulation is activation of genes encoding proteins that inhibit cell proliferation. Hubbi et al. report that the á subunit of HIF-1 (HIF-1α) also inhibits cell proliferation in response to hypoxia by inhibiting the activity of a DNA helicase that is required for DNA replication.

Original language	English (US)
Article number	pc5
Journal	Science signaling
Volume	6
Issue number	262
DOIs	https://doi.org/10.1126/scisignal.2004007
State	Published - Feb 12 2013

Keywords

Anoxia
Cell proliferation
Cell stress
DNA replication
HIF-1α
Hypoxia
Hypoxia-inducible factor 1α
Science Signaling
Transcription factor

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1126/scisignal.2004007

Cite this

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title = "Science signaling podcast: 12 February 2013",

abstract = "This Podcast features an interview Gregg Semenza and Maimon Hubbi, authors of a paper that appears in the 12 February 2013 issue of Science Signaling. Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric protein that mediates the transcriptional response to hypoxia, the decreased availability of oxygen. One of the outcomes of HIF-1α mediated gene regulation is activation of genes encoding proteins that inhibit cell proliferation. Hubbi et al. report that the {\'a} subunit of HIF-1 (HIF-1α) also inhibits cell proliferation in response to hypoxia by inhibiting the activity of a DNA helicase that is required for DNA replication.",

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AB - This Podcast features an interview Gregg Semenza and Maimon Hubbi, authors of a paper that appears in the 12 February 2013 issue of Science Signaling. Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric protein that mediates the transcriptional response to hypoxia, the decreased availability of oxygen. One of the outcomes of HIF-1α mediated gene regulation is activation of genes encoding proteins that inhibit cell proliferation. Hubbi et al. report that the á subunit of HIF-1 (HIF-1α) also inhibits cell proliferation in response to hypoxia by inhibiting the activity of a DNA helicase that is required for DNA replication.

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Science signaling podcast: 12 February 2013

Abstract

Keywords

ASJC Scopus subject areas

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