Science signaling podcast: 12 February 2013

Gregg L Semenza, Maimon E. Hubbi, Annalisa M. VanHook

Research output: Contribution to journalArticle

Abstract

This Podcast features an interview Gregg Semenza and Maimon Hubbi, authors of a paper that appears in the 12 February 2013 issue of Science Signaling. Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric protein that mediates the transcriptional response to hypoxia, the decreased availability of oxygen. One of the outcomes of HIF-1α mediated gene regulation is activation of genes encoding proteins that inhibit cell proliferation. Hubbi et al. report that the á subunit of HIF-1 (HIF-1α) also inhibits cell proliferation in response to hypoxia by inhibiting the activity of a DNA helicase that is required for DNA replication.

Original languageEnglish (US)
Article numberpc5
JournalScience Signaling
Volume6
Issue number262
DOIs
Publication statusPublished - Feb 12 2013

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Keywords

  • Anoxia
  • Cell proliferation
  • Cell stress
  • DNA replication
  • HIF-1α
  • Hypoxia
  • Hypoxia-inducible factor 1α
  • Science Signaling
  • Transcription factor

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Molecular Biology

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