Sciatic nerve stimulation does not increase endogenous adenosine production in sensory-motor cortex

Frances Northington, G. Paul Matherne, Sharon D. Coleman, Robert M. Berne

Research output: Contribution to journalArticle


Adenosine participates in the coupling of cerebral blood flow to oxygen consumption in the brain during such stimuli as hypoxia, ischemia, and seizures. It has been suggested that it also participates in the regulation of cerebral blood flow during somatosensory stimulation, a condition during which cerebral blood flow and oxygen consumption appear to be uncoupled. Interstitial adenosine was estimated by the microdialysis technique and cerebral blood flow was measured by hydrogen clearance in the hindlimb sensory-motor cortex during sciatic nerve stimulation. Cerebral blood flow increased from 102 to 188 ml min-1 100 g-1 (p <0.001) in the cortex con-tralateral to the stimulated leg without an associated increase in interstitial adenosine (baseline 0.624 (μM stimulation 0.583 μM). Infusion of the adenosine antagonist 8-sulfophenyltheophylline failed to block an increase in cerebral blood flow during central sciatic nerve stimulation, but decreased basal cerebral blood flow (69 ml min-1 100 g-1). These results suggest that adenosine does not mediate changes in cerebral blood flow during somatosensory stimulation, but may participate in the regulation of cerebral blood flow in the basal state.

Original languageEnglish (US)
Pages (from-to)835-843
Number of pages9
JournalJournal of Cerebral Blood Flow and Metabolism
Issue number5
Publication statusPublished - 1992
Externally publishedYes



  • Adenosine
  • Cerebral blood flow
  • Sensory-motor cortex

ASJC Scopus subject areas

  • Endocrinology
  • Neuroscience(all)
  • Endocrinology, Diabetes and Metabolism

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