Schwann cell-derived periostin promotes autoimmune peripheral polyneuropathy via macrophage recruitment

Denise E. Allard, Yan Wang, Jian Joel Li, Bridget Conley, Erin W. Xu, David Sailer, Caellaigh Kimpston, Rebecca Notini, Collin Jamal Smith, Emel Koseoglu, Joshua Starmer, Xiaopei L. Zeng, James F. Howard, Ahmet Hoke, Steven S. Scherer, Maureen A. Su

Research output: Contribution to journalArticle

Abstract

Chronic inflammatory demyelinating polyneuropathy (CIDP) and Guillain-Barre syndrome (GBS) are inflammatory neuropathies that affect humans and are characterized by peripheral nerve myelin destruction and macrophage-containing immune infiltrates. In contrast to the traditional view that the peripheral nerve is simply the target of autoimmunity, we report here that peripheral nerve Schwann cells exacerbate the autoimmune process through extracellular matrix (ECM) protein induction. In a spontaneous autoimmune peripheral polyneuropathy (SAPP) mouse model of inflammatory neuropathy and CIDP nerve biopsies, the ECM protein periostin (POSTN) was upregulated in affected sciatic nerves and was primarily expressed by Schwann cells. Postn deficiency delayed the onset and reduced the extent of neuropathy, as well as decreased the number of macrophages infiltrating the sciatic nerve. In an in vitro assay, POSTN promoted macrophage chemotaxis in an integrin-AM (ITGAM) and ITGAV-dependent manner. The PNS-infiltrating macrophages in SAPP-affected nerves were pathogenic, since depletion of macrophages protected against the development of neuropathy. Our findings show that Schwann cells promote macrophage infiltration by upregulating Postn and suggest that POSTN is a novel target for the treatment of macrophage-associated inflammatory neuropathies.

Original languageEnglish (US)
Pages (from-to)4727-4741
Number of pages15
JournalJournal of Clinical Investigation
Volume128
Issue number10
DOIs
StatePublished - Oct 1 2018

ASJC Scopus subject areas

  • Medicine(all)

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    Allard, D. E., Wang, Y., Li, J. J., Conley, B., Xu, E. W., Sailer, D., Kimpston, C., Notini, R., Smith, C. J., Koseoglu, E., Starmer, J., Zeng, X. L., Howard, J. F., Hoke, A., Scherer, S. S., & Su, M. A. (2018). Schwann cell-derived periostin promotes autoimmune peripheral polyneuropathy via macrophage recruitment. Journal of Clinical Investigation, 128(10), 4727-4741. https://doi.org/10.1172/JCI99308