Schwann cell and glial responses in β,β ′-iminodipropionitrile intoxication. I. Schwann cell and oligodendrocyte ingrowths

John W. Griffin, Donald L. Price

Research output: Contribution to journalArticle

Abstract

In rats continuously exposed to β,β′-iminodipropionitrile (IDPN) for long periods, numerous Schwann cell and oligodendrocyte ingrowths extending into giant axonal swellings were found. These ingrowths, cytoplasmic processes of the Schwann cells and oligodendrocytes which deeply indented the axon, regularly arose from Schmidt-Lanterman clefts in the internodes. They dissected along an intra-axonal 'cleavage plane' which separated the giant axonal swellings into two compartments: an inner central channel of relatively normal axoplasm and an outer 'axoplasmic pad' comprised of circularly or spirally-arranged masses of neurofilaments. Multiple ingrowths often arose within a single internode, resulting in nearly complete segregation of the axoplasmic pad from the central channel over long distances. At the interface between the two axoplasmic compartments, internal myelin sheaths were occasionally found. The distinctive ingrowths found in this study appear to represent unusual responses of the Schwann cells and oligodendrocytes to the primary neurofilamentous axonal pathology produced by IDPN.

Original languageEnglish (US)
Pages (from-to)995-1007
Number of pages13
JournalJournal of Neurocytology
Volume10
Issue number6
DOIs
StatePublished - Dec 1981

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Schwann Cells
Oligodendroglia
Neuroglia
Intermediate Filaments
Myelin Sheath
Axons
Pathology

ASJC Scopus subject areas

  • Neuroscience(all)
  • Histology
  • Anatomy
  • Cell Biology

Cite this

Schwann cell and glial responses in β,β ′-iminodipropionitrile intoxication. I. Schwann cell and oligodendrocyte ingrowths. / Griffin, John W.; Price, Donald L.

In: Journal of Neurocytology, Vol. 10, No. 6, 12.1981, p. 995-1007.

Research output: Contribution to journalArticle

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