Schizophrenia

Gender and familial risk

Paula S. Wolyniec, Ann E Pulver, John A. McGrath, Doreen Tam

Research output: Contribution to journalArticle

Abstract

The morbid risks for schizophrenia and any nonaffective psychosis in the first degree relatives of male and female schizophrenic probands were compared utilizing Cox proportional hazards models. The schizophrenic probands (275 male; 106 female) were drawn from a larger sample of hospitalized patients obtained by systematically screening all psychiatric admissions to 15 facilities over a six-year period. Proband diagnoses (DSM-III) were based on a direct assessment of the patient and a review of medical records. The family history method was used to obtain information about the first degree relatives of the probands. Cox proportional hazards models were adjusted for duration of illness of the proband and gender of the relatives. First degree relatives of female probands had significantly higher morbid risks for schizophrenia and nonaffective phychosis than relatives of male probands. The differential risk for schizophrenia in the relatives of male and female probands demonstrated in this study, as well as others, suggests that males and females may be at different risk for subtypes of the disorder.

Original languageEnglish (US)
Pages (from-to)17-27
Number of pages11
JournalJournal of Psychiatric Research
Volume26
Issue number1
DOIs
StatePublished - 1992

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Schizophrenia
Proportional Hazards Models
Diagnostic and Statistical Manual of Mental Disorders
Psychotic Disorders
Medical Records
Psychiatry

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

Cite this

Schizophrenia : Gender and familial risk. / Wolyniec, Paula S.; Pulver, Ann E; McGrath, John A.; Tam, Doreen.

In: Journal of Psychiatric Research, Vol. 26, No. 1, 1992, p. 17-27.

Research output: Contribution to journalArticle

Wolyniec, Paula S. ; Pulver, Ann E ; McGrath, John A. ; Tam, Doreen. / Schizophrenia : Gender and familial risk. In: Journal of Psychiatric Research. 1992 ; Vol. 26, No. 1. pp. 17-27.
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