Schizophrenia: age at onset, gender and familial risk

A. E. Pulver, C. H. Brown, P. Wolyniec, J. McGrath, D. Tam, L. Adler, W. T. Carpenter, B. Childs

Research output: Contribution to journalArticle

Abstract

In a family history study of 366 schizophrenic probands and their 1851 first‐degree relatives, we found a relationship between age at onset of psychosis in the male probands and the risk for schizophrenia in their relatives. The relatives of male schizophrenic probands whose onset of psychosis occurred when they were younger than 17 years of age had an increased risk of schizophrenia when compared with the relatives of male probands with an age at onset greater than 17. We did not find an association between age at onset of psychosis in the female probands and familial risk. Cox proportional hazards models permitted us to examine the relationship between age at onset of psychosis in the probands and familial risk while controlling for possible confounding effects.

Original languageEnglish (US)
Pages (from-to)344-351
Number of pages8
JournalActa Psychiatrica Scandinavica
Volume82
Issue number5
DOIs
StatePublished - Nov 1990

Keywords

  • Key words
  • age at onset
  • family
  • schizophrenia
  • sex difference

ASJC Scopus subject areas

  • Psychiatry and Mental health

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  • Cite this

    Pulver, A. E., Brown, C. H., Wolyniec, P., McGrath, J., Tam, D., Adler, L., Carpenter, W. T., & Childs, B. (1990). Schizophrenia: age at onset, gender and familial risk. Acta Psychiatrica Scandinavica, 82(5), 344-351. https://doi.org/10.1111/j.1600-0447.1990.tb01399.x