Schizophrenia

Michael J. Owen, Akira Sawa, Preben B. Mortensen

Research output: Contribution to journalArticle

Abstract

Schizophrenia is a complex, heterogeneous behavioural and cognitive syndrome that seems to originate from disruption of brain development caused by genetic or environmental factors, or both. Dysfunction of dopaminergic neurotransmission contributes to the genesis of psychotic symptoms, but evidence also points to a widespread and variable involvement of other brain areas and circuits. Disturbances of synaptic function might underlie abnormalities of neuronal connectivity that possibly involves interneurons, but the precise nature, location, and timing of these events are uncertain. At present, treatment mainly consists of antipsychotic drugs combined with psychological therapies, social support, and rehabilitation, but a pressing need for more effective treatments and delivery of services exists. Advances in genomics, epidemiology, and neuroscience have led to great progress in understanding the disorder, and the opportunities for further scientific breakthrough are numerous-but so are the challenges.

Original languageEnglish (US)
JournalThe Lancet
DOIs
StateAccepted/In press - 2015

Fingerprint

Schizophrenia
Brain
Interneurons
Neurosciences
Genomics
Synaptic Transmission
Social Support
Antipsychotic Agents
Epidemiology
Therapeutics
Rehabilitation
Psychology

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Owen, M. J., Sawa, A., & Mortensen, P. B. (Accepted/In press). Schizophrenia. The Lancet. https://doi.org/10.1016/S0140-6736(15)01121-6

Schizophrenia. / Owen, Michael J.; Sawa, Akira; Mortensen, Preben B.

In: The Lancet, 2015.

Research output: Contribution to journalArticle

Owen, Michael J. ; Sawa, Akira ; Mortensen, Preben B. / Schizophrenia. In: The Lancet. 2015.
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