SchizConnect: Virtual Data integration in neuroimaging

Jose Luis Ambite, Marcelo Tallis, Kathryn Alpert, David B. Keator, Margaret King, Drew Landis, George Konstantinidis, Vince D. Calhoun, Steven G. Potkin, Jessica A. Turner, Lei Wang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

In many scientific domains, including neuroimaging studies, there is a need to obtain increasingly larger cohorts to achieve the desired statistical power for discovery. However, the economics of imaging studies make it unlikely that any single study or consortia can achieve the desired sample sizes. What is needed is an architecture that can easily incorporate additional studies as they become available. We present such architecture based on a virtual data integration approach, where data remains at the original sources, and is retrieved and harmonized in response to user queries. This is in contrast to approaches that move the data to a central warehouse. We implemented our approach in the SchizConnect system that integrates data from three neuroimaging consortia on Schizophrenia: FBIRN’s Human Imaging Database (HID), MRN’s Collaborative Imaging and Neuroinformatics System (COINS), and the NUSDAST project at XNAT Central. A portal providing harmonized access to these sources is publicly deployed at schizconnect.org.

Original languageEnglish (US)
Title of host publicationData Integration in the Life Sciences - 11th International Conference, DILS 2015, Proceedings
EditorsJose-Luis Ambite, Ashish N. Naveen
PublisherSpringer Verlag
Pages37-51
Number of pages15
ISBN (Print)9783319218427
DOIs
StatePublished - 2015
Event11th International Conference on Data Integration in the Life Sciences, DILS 2015 - Los Angeles, United States
Duration: Jul 9 2015Jul 10 2015

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume9162
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Other

Other11th International Conference on Data Integration in the Life Sciences, DILS 2015
CountryUnited States
CityLos Angeles
Period7/9/157/10/15

Keywords

  • Data integration
  • Mediation
  • Neuroimaging
  • Schema mappings

ASJC Scopus subject areas

  • Theoretical Computer Science
  • Computer Science(all)

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