TY - JOUR
T1 - Scheie Syndrome and Macular Corneal Dystrophy
T2 - An Ultrastructural Comparison of Conjunctiva and Skin
AU - Quigley, Harry A.
AU - Goldberg, Morton F.
PY - 1971/5
Y1 - 1971/5
N2 - In the first electron microscope study of tissue from a patient with mucopolysaccharidosis type V (Scheie syndrome), multiple vacuolations were seen in fibroblasts from conjunctiva and skin and in conjunctival epithelial cells. Inclusions were single membrane-limited, contained a granulofibrillar material, and were associated with Golgi areas. Skin epithelium was normal. Skin and bulbar conjunctiva from the inferior fornix in four patients with macular corneal dystrophy were normal. In one macular dystrophy patient, a second conjunctival biopsy, taken 2 mm from the limbus, showed fibroblasts with dilated rough endoplasmic reticulum.
AB - In the first electron microscope study of tissue from a patient with mucopolysaccharidosis type V (Scheie syndrome), multiple vacuolations were seen in fibroblasts from conjunctiva and skin and in conjunctival epithelial cells. Inclusions were single membrane-limited, contained a granulofibrillar material, and were associated with Golgi areas. Skin epithelium was normal. Skin and bulbar conjunctiva from the inferior fornix in four patients with macular corneal dystrophy were normal. In one macular dystrophy patient, a second conjunctival biopsy, taken 2 mm from the limbus, showed fibroblasts with dilated rough endoplasmic reticulum.
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U2 - 10.1001/archopht.1971.00990050555006
DO - 10.1001/archopht.1971.00990050555006
M3 - Article
C2 - 4253322
AN - SCOPUS:0015062946
SN - 0003-9950
VL - 85
SP - 553
EP - 564
JO - Archives of ophthalmology
JF - Archives of ophthalmology
IS - 5
ER -