TY - JOUR
T1 - SCH-39304 in prevention and treatment of disseminated candidiasis in persistently granulocytopenic rabbits
AU - Walsh, T. J.
AU - Lee, J. W.
AU - Lecciones, J.
AU - Kelly, P.
AU - Peter, J.
AU - Thomas, V.
AU - Bacher, J.
AU - Pizzo, P. A.
PY - 1990
Y1 - 1990
N2 - To investigate the potential use of SCH-39304 for the prevention and treatment of disseminated candidiasis in granulocytopenic patients, we studied its in vivo antifungal activity as preventive, early, and late treatments in three models (acute, subacute, and chronic) of disseminated candidiasis in persistently granulocytopenic rabbits. SCH-39304 was as effective as amphotericin B alone and fluconazole alone for the prevention of disseminated candidiasis. SCH-39304 alone and fluconazole alone were as effective as amphotericin B plus flucytosine for early treatemnt of subacute disseminated candidiasis. When treatment was delayed for 5 days to establish chronic disseminated candidiasis, SCH-39304 was less effective than amphotericin B plus glucytosine. In comparison with different treatment regimens, SCH-39304 was more effective in early and preventive treatment. Thus, SCH-39304 was comparable to treatment control regimens in prevention and early treatment of subacute disseminated candidiasis. SCH-39304 also was most effective in granulocytopenic rabbits with disseminated candidiasis when used for prevention or early treatment.
AB - To investigate the potential use of SCH-39304 for the prevention and treatment of disseminated candidiasis in granulocytopenic patients, we studied its in vivo antifungal activity as preventive, early, and late treatments in three models (acute, subacute, and chronic) of disseminated candidiasis in persistently granulocytopenic rabbits. SCH-39304 was as effective as amphotericin B alone and fluconazole alone for the prevention of disseminated candidiasis. SCH-39304 alone and fluconazole alone were as effective as amphotericin B plus flucytosine for early treatemnt of subacute disseminated candidiasis. When treatment was delayed for 5 days to establish chronic disseminated candidiasis, SCH-39304 was less effective than amphotericin B plus glucytosine. In comparison with different treatment regimens, SCH-39304 was more effective in early and preventive treatment. Thus, SCH-39304 was comparable to treatment control regimens in prevention and early treatment of subacute disseminated candidiasis. SCH-39304 also was most effective in granulocytopenic rabbits with disseminated candidiasis when used for prevention or early treatment.
UR - http://www.scopus.com/inward/record.url?scp=0025125486&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025125486&partnerID=8YFLogxK
U2 - 10.1128/AAC.34.8.1560
DO - 10.1128/AAC.34.8.1560
M3 - Article
C2 - 2221866
AN - SCOPUS:0025125486
SN - 0066-4804
VL - 34
SP - 1560
EP - 1564
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 8
ER -