Scatter factor/hepatocyte growth factor expression enhances human glioblastoma tumorigenicity and growth

John Laterra, Eliot Rosen, Myeong Nam, Srikanth Ranganathan, Kevin Fielding, Peter Johnston

Research output: Contribution to journalArticlepeer-review

Abstract

We have shown previously that the multifunctional cytokine scatter factor/hepatocyte growth factor (SF/HGF) is elevated in human malignant gliomas. In this study we investigated how human SF/HGF expression affects the malignancy of the U373 human glioblastoma cell line in vivo and in vitro. Human SF/HGF gene transfer increased U373 glioblastoma tumorigenicity by ≤ 2O-fold and enhanced the growth rate of intracerebral U373 xenografts by 3- to 8-fold. SF/HGF expression had no effect on the proliferation of glioblastoma cell monolayers but increased their anchorage-independent colony formation in soft agar by 5- to 8-fold. These results are the first to show that SF/HGF expression by human glioblastoma cells enhances their growth dysregulation in vitro and malignancy in vivo.

Original languageEnglish (US)
Pages (from-to)743-747
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume235
Issue number3
DOIs
StatePublished - Jun 27 1997

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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