ScaPD: A database for human scaffold proteins

Xiaomei Han, Jenny Wang, Jie Wang, Sheng Liu, Jianfei Hu, Heng Zhu, Jiang Qian

Research output: Contribution to journalArticle

Abstract

Background: Scaffold proteins play a critical role in an increasing number of biological signaling processes, including simple tethering mechanism, regulating selectivity in pathways, shaping cellular behaviors. While many databases document the signaling pathways, few databases are devoted to the scaffold proteins that medicate signal transduction. Results: Here, we have developed a user-friendly database, ScaPD, to describe computationally predicted, experimentally validated scaffold proteins and associated signaling pathways. It currently contains 273 scaffold proteins and 1118 associated signaling pathways. The database allows users to search, navigate and download the scaffold protein-mediated signaling networks. Conclusions: Manually curated and predicted scaffold protein data will be a foundation for further investigation of the scaffold protein in the signal transduction. With maintained up-to-date data, ScaPD ( http://bioinfo.wilmer.jhu.edu/ScaPD ) will be a valuable resource for understanding how individual signaling pathways are regulated.

Original languageEnglish (US)
Article number386
JournalBMC Bioinformatics
Volume18
DOIs
StatePublished - Oct 3 2017

Keywords

  • Database
  • Scaffold protein
  • Signaling pathway

ASJC Scopus subject areas

  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Computer Science Applications
  • Applied Mathematics

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