Scan-Rescan reproducibility of carotid bifurcation geometry from routine contrast-enhanced MR angiography

Payam B. Bijari, Luca Antiga, Bruce A. Wasserman, David A. Steinman

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Purpose To demonstrate the feasibility of rapid and reliable geometric characterization of normal carotid bifurcation geometry from routine 3D contrast-enhanced magnetic resonance (MR) angiograms. Materials and Methods Repeat scans of 61 participants, acquired as part of the Atherosclerosis Risk in Communities (ARIC) Carotid MRI substudy, were digitally segmented using automated 3D level set methods, relying on an operator only to select the branch endpoints and thresholds for the 3D lumen surface initialization. Geometric factors characterizing the 3D lumen geometry were then extracted automatically. Results Of 122 scans, 117 could be segmented within 5 minutes each, with 40% being of sufficiently high quality to require less than 2 minutes each. Irrespective of scan quality, geometric factors were found to be highly reproducible, with intraclass correlation coefficients (ICCs) typically above 0.9. The reconstructed lumen surfaces were reproducible to <0.3 mm on average, comparable to previous MRI-based reproducibility studies. Owing to the automated nature of the analysis, operator reliability was near-perfect (ICC >0.99), with lumen surface differences <0.1 mm. Conclusion The 3D geometry of the carotid bifurcation can be characterized rapidly and with a high degree of consistency, even for suboptimal image qualities. This bodes well for large-scale retrospective or prospective studies aimed at teasing out the influence of local vs. systemic risk factors for early atherosclerosis.

Original languageEnglish (US)
Pages (from-to)482-489
Number of pages8
JournalJournal of Magnetic Resonance Imaging
Issue number2
StatePublished - Feb 2011


  • atherosclerosis
  • carotid bifurcation
  • geometric risk factors
  • magnetic resonance angiography
  • reproducibility

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Scan-Rescan reproducibility of carotid bifurcation geometry from routine contrast-enhanced MR angiography'. Together they form a unique fingerprint.

Cite this