Scaling up high-impact interventions: How is it done?

Jeffrey Michael Smith, Joseph De Graft-Johnson, Pashtoon Zyaee, Jim Ricca, Judith Fullerton

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Building upon the World Health Organization's ExpandNet framework, 12 key principles of scale-up have emerged from the implementation of maternal and newborn health interventions. These principles are illustrated by three case studies of scale up of high-impact interventions: the Helping Babies Breathe initiative; pre-service midwifery education in Afghanistan; and advanced distribution of misoprostol for self-administration at home births to prevent postpartum hemorrhage. Program planners who seek to scale a maternal and/or newborn health intervention must ensure that: the necessary evidence and mechanisms for local ownership for the intervention are well-established; the intervention is as simple and cost-effective as possible; and the implementers and beneficiaries of the intervention are working in tandem to build institutional capacity at all levels and in consideration of all perspectives.

Original languageEnglish (US)
Pages (from-to)S4-S10
JournalInternational Journal of Gynecology and Obstetrics
Issue numberS2
StatePublished - Jun 1 2015
Externally publishedYes


  • Helping Babies Breathe
  • Maternal and newborn health
  • Midwifery
  • Misoprostol
  • Scale-up

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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