Scales as outcome measures for Alzheimer's disease

Ronald Black, Barry Greenberg, J. Michael Ryan, Holly Posner, Jeffrey Seeburger, Joan Amatniek, Malca Resnick, Richard Mohs, David S. Miller, Daniel Saumier, Maria C. Carrillo, Yaakov Stern

Research output: Contribution to journalEditorial

Abstract

The assessment of patient outcomes in clinical trials of new therapeutics for Alzheimer's disease (AD) continues to evolve. In addition to assessing drugs for symptomatic relief, an increasing number of trials are focusing on potential disease-modifying agents. Moreover, participants with AD are being studied earlier in their course of disease. As a result, the limitations of current outcome measures have become more apparent, as has the need for better instruments. In recognition of the need to review and possibly revise current assessment measures, the Alzheimer's Association, in cooperation with industry leaders and academic investigators, convened a Research Roundtable meeting devoted to scales as outcome measures for AD clinical trials. The meeting included a discussion of methodological issues in the use of scales in AD clinical trials, including cross-cultural issues. Specific topics related to the use of cognitive, functional, global, and neuropsychiatric scales were also presented. Speakers also addressed academic and industry initiatives for pooling data from untreated and placebo-treated patients in clinical trials. A number of regulatory topics were also discussed with agency representatives. Panel discussions highlighted areas of controversy, in an effort to gain consensus on various topics.

Original languageEnglish (US)
Pages (from-to)324-339
Number of pages16
JournalAlzheimer's and Dementia
Volume5
Issue number4
DOIs
StatePublished - Jul 1 2009
Externally publishedYes

Keywords

  • Cognitive testing
  • Functional scale
  • Global scale
  • Neuropsychological assessment
  • Outcome measure

ASJC Scopus subject areas

  • Epidemiology
  • Health Policy
  • Developmental Neuroscience
  • Clinical Neurology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

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  • Cite this

    Black, R., Greenberg, B., Ryan, J. M., Posner, H., Seeburger, J., Amatniek, J., Resnick, M., Mohs, R., Miller, D. S., Saumier, D., Carrillo, M. C., & Stern, Y. (2009). Scales as outcome measures for Alzheimer's disease. Alzheimer's and Dementia, 5(4), 324-339. https://doi.org/10.1016/j.jalz.2009.05.667