Scaffolds for musculoskeletal tissue engineering

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Tissue engineering, with the use of cells and scaffolds, has important clinical application in regenerative medicine. Additionally, these technologies can also be applied to the study of cellular biology, specifically, the cellular interactions within organized scaffolds, and the effects of paracrine communication between different cell types. The main focus of this chapter will be on the cell-matrix interactions and the communications between normal and diseased cells within organized scaffolds. In addition, this chapter will review the different cell types utilized in musculoskeletal tissue engineering with a focus on the application of mesenchymal stem cells in therapeutic scenarios, summarize the use of natural and synthetic biomaterials in tissue engineering and their combination into organized scaffolds, and discuss how cytokines affect tissue growth and disease development through the stimulation of matrix metalloproteinases.

Original languageEnglish (US)
Title of host publicationRegenerative Medicine and Biomaterials for the Repair of Connective Tissues
PublisherElsevier Ltd
Pages301-329
Number of pages29
ISBN (Print)9781845694173
DOIs
StatePublished - Jan 2010

Keywords

  • Matrix metalloproteinases
  • Mesenchymal stem cells
  • Osteoarthritis
  • Paracrine communication
  • Scaffolds

ASJC Scopus subject areas

  • Materials Science(all)

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  • Cite this

    Li, H., & Elisseeff, J. H. (2010). Scaffolds for musculoskeletal tissue engineering. In Regenerative Medicine and Biomaterials for the Repair of Connective Tissues (pp. 301-329). Elsevier Ltd. https://doi.org/10.1533/9781845697792.1.301