Scaffold-Mediated Sustained, Non-viral Delivery of miR-219/miR-338 Promotes CNS Remyelination

Ulla Milbreta, Junquan Lin, Coline Pinese, William Ong, Jiah Shin Chin, Hitomi Shirahama, Ruifa Mi, Anna Williams, Marie E. Bechler, Jun Wang, Charles ffrench-Constant, Ahmet Hoke, Sing Yian Chew

Research output: Contribution to journalArticlepeer-review

Abstract

Milbreta et al. demonstrate that the non-viral delivery of miR-219 and miR-338 using a hybrid electrospun fiber-hydrogel scaffold can promote the survival of oligodendrocyte progenitor cells (OPCs) in a lacerated spinal cord. Besides that, this cocktail can enhance the rate and extent of OPC differentiation and subsequent remyelination in the implant interface and within the scaffold.

Original languageEnglish (US)
Pages (from-to)411-423
Number of pages13
JournalMolecular Therapy
Volume27
Issue number2
DOIs
StatePublished - Feb 6 2019

Keywords

  • CNS
  • electrospinning
  • gene silencing
  • microRNA
  • myelination
  • non-viral
  • oligodendrocytes
  • regeneration
  • scaffold
  • sustained

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Genetics
  • Pharmacology
  • Drug Discovery

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