Scaffold design for cartilage tissue engineering

Jennifer Elisseeff, Robert Langer, Yoshihiko Yamada

Research output: Contribution to journalConference article

Abstract

A study was conducted to develop a minimally invasive method to implant polymers using photopolymerization and analyze gene expression. Photopolymerization was applied to cartilage tissue engineering using a model hydrogel system of poly(ethylene oxide)-dimethacrylate and poly(ethylene glycol). Chondrocytes were photoencapsulated in vitro and in nude mice using transdermal photopolymerization. In vitro and in vivo experiments demonstrated chondrocyte survival and extracellular matrix production through biochemical and mechanical evaluation. Growth factors added to the hydrogel significantly increased proteoglycan concentration and cell number.

Original languageEnglish (US)
Pages (from-to)S-5
JournalAnnals of biomedical engineering
Volume28
Issue numberSUPPL. 1
StatePublished - Dec 1 2000
Externally publishedYes
Event2000 Annual Fall Meeting of the Biomedical Engineering Society - Washington, WA, USA
Duration: Oct 12 2000Oct 14 2000

ASJC Scopus subject areas

  • Biomedical Engineering

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