Abstract
In this issue of Cancer Discovery, Witherspoon and colleagues use an unbiased metabolite profiling approach to study the effects of polyamine depletion by 2-difluoromethylornithine in colon cancer cells. Their surprising findings indicate that it is a decrease in thymidine pools resulting from altered tetrahydrofolate availability rather than decreases in polyamines that produces cytostasis.
Original language | English (US) |
---|---|
Pages (from-to) | 975-977 |
Number of pages | 3 |
Journal | Cancer discovery |
Volume | 3 |
Issue number | 9 |
DOIs | |
State | Published - Sep 2013 |
ASJC Scopus subject areas
- Oncology