Say what? The activity of the polyamine biosynthesis inhibitor difluoromethylornithine in chemoprevention is a result of reduced thymidine pools?

Research output: Contribution to journalArticlepeer-review

Abstract

In this issue of Cancer Discovery, Witherspoon and colleagues use an unbiased metabolite profiling approach to study the effects of polyamine depletion by 2-difluoromethylornithine in colon cancer cells. Their surprising findings indicate that it is a decrease in thymidine pools resulting from altered tetrahydrofolate availability rather than decreases in polyamines that produces cytostasis.

Original languageEnglish (US)
Pages (from-to)975-977
Number of pages3
JournalCancer discovery
Volume3
Issue number9
DOIs
StatePublished - Sep 2013

ASJC Scopus subject areas

  • Oncology

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