Saving the sweetness: Renal glucose handling in health and disease

Blythe D. Shepard, Jennifer L. Pluznick

Research output: Contribution to journalReview articlepeer-review

Abstract

Glucose homeostasis is highly controlled, and the function of the kidney plays an integral role in this process. The exquisite control of blood glucose relies, in part, on renal glucose filtration, renal glucose reabsorption, and renal gluconeogenesis. Particularly critical to maintaining glucose homeostasis is the renal reabsorption of glucose; with ~162 g of glucose filtered by the kidney per day, it is imperative that the kidney have the ability to efficiently reabsorb nearly 100% of this glucose back in the bloodstream. In this review, we focus on this central process, highlighting the renal transporters and regulators involved in both the physiology and pathophysiology of glucose reabsorption.

Original languageEnglish (US)
Pages (from-to)F55-F61
JournalAmerican Journal of Physiology - Renal Physiology
Volume313
Issue number1
DOIs
StatePublished - 2017

Keywords

  • Glucose reabsorption
  • Glucose transporter 2
  • Proximal tubule
  • Sodium-glucose cotransporter 1
  • Sodium-glucose cotransporter 2

ASJC Scopus subject areas

  • Physiology
  • Urology

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