TY - JOUR
T1 - Saving the sweetness
T2 - Renal glucose handling in health and disease
AU - Shepard, Blythe D.
AU - Pluznick, Jennifer L.
N1 - Funding Information:
This work was supported by National Institute of Diabetes and Digestive and Kidney Diseases Grants F32-DK-096780 and K01-DK-106400.
Publisher Copyright:
© 2017 the American Physiological Society.
PY - 2017
Y1 - 2017
N2 - Glucose homeostasis is highly controlled, and the function of the kidney plays an integral role in this process. The exquisite control of blood glucose relies, in part, on renal glucose filtration, renal glucose reabsorption, and renal gluconeogenesis. Particularly critical to maintaining glucose homeostasis is the renal reabsorption of glucose; with ~162 g of glucose filtered by the kidney per day, it is imperative that the kidney have the ability to efficiently reabsorb nearly 100% of this glucose back in the bloodstream. In this review, we focus on this central process, highlighting the renal transporters and regulators involved in both the physiology and pathophysiology of glucose reabsorption.
AB - Glucose homeostasis is highly controlled, and the function of the kidney plays an integral role in this process. The exquisite control of blood glucose relies, in part, on renal glucose filtration, renal glucose reabsorption, and renal gluconeogenesis. Particularly critical to maintaining glucose homeostasis is the renal reabsorption of glucose; with ~162 g of glucose filtered by the kidney per day, it is imperative that the kidney have the ability to efficiently reabsorb nearly 100% of this glucose back in the bloodstream. In this review, we focus on this central process, highlighting the renal transporters and regulators involved in both the physiology and pathophysiology of glucose reabsorption.
KW - Glucose reabsorption
KW - Glucose transporter 2
KW - Proximal tubule
KW - Sodium-glucose cotransporter 1
KW - Sodium-glucose cotransporter 2
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U2 - 10.1152/ajprenal.00046.2017
DO - 10.1152/ajprenal.00046.2017
M3 - Review article
C2 - 28356283
AN - SCOPUS:85021940772
SN - 0363-6127
VL - 313
SP - F55-F61
JO - American Journal of Physiology - Renal Physiology
JF - American Journal of Physiology - Renal Physiology
IS - 1
ER -