SAS, a gene amplified in human sarcomas, encodes a new member of the transmembrane 4 superfamily of proteins

Sheryl A. Jankowski; Deanna S. Mitchell; Sharon H. Smith; Jeffrey M. Trent; Paul S. Meltzer

SAS, a gene amplified in human sarcomas, encodes a new member of the transmembrane 4 superfamily of proteins

Sheryl A. Jankowski, Deanna S. Mitchell, Sharon H. Smith, Jeffrey M. Trent, Paul S. Meltzer

Research output: Contribution to journal › Article › peer-review

Abstract

Amplification of 12q13-14 occurs in a subset of human sarcomas including malignant fibrous histiocytoma and liposarcoma. This chromosomal region has previously been found to include a number of growth-related genes including the GLI proto-oncogene and the p53-associated protein, MDM2. We now report the characterization of SAS (sarcoma amplified sequence), a novel transcript found in this region. Sequence analysis demonstrates that SAS is a novel member of a transmembrane protein family (transmembrane 4 superfamily or TM4SF) thought to be involved in growth-related cellular processes. This observation adds a TM4SF protein to the cluster of genes at 12q13-14 frequently amplified in human sarcomas.

Original language	English (US)
Pages (from-to)	1205-1211
Number of pages	7
Journal	Oncogene
Volume	9
Issue number	4
State	Published - Apr 1994
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

Cite this

@article{cbaed4d64a62440fbc10e7167c1e9b9d,

title = "SAS, a gene amplified in human sarcomas, encodes a new member of the transmembrane 4 superfamily of proteins",

abstract = "Amplification of 12q13-14 occurs in a subset of human sarcomas including malignant fibrous histiocytoma and liposarcoma. This chromosomal region has previously been found to include a number of growth-related genes including the GLI proto-oncogene and the p53-associated protein, MDM2. We now report the characterization of SAS (sarcoma amplified sequence), a novel transcript found in this region. Sequence analysis demonstrates that SAS is a novel member of a transmembrane protein family (transmembrane 4 superfamily or TM4SF) thought to be involved in growth-related cellular processes. This observation adds a TM4SF protein to the cluster of genes at 12q13-14 frequently amplified in human sarcomas.",

author = "Jankowski, {Sheryl A.} and Mitchell, {Deanna S.} and Smith, {Sharon H.} and Trent, {Jeffrey M.} and Meltzer, {Paul S.}",

year = "1994",

month = apr,

language = "English (US)",

volume = "9",

pages = "1205--1211",

journal = "Oncogene",

issn = "0950-9232",

publisher = "Nature Publishing Group",

number = "4",

}

TY - JOUR

T1 - SAS, a gene amplified in human sarcomas, encodes a new member of the transmembrane 4 superfamily of proteins

AU - Jankowski, Sheryl A.

AU - Mitchell, Deanna S.

AU - Smith, Sharon H.

AU - Trent, Jeffrey M.

AU - Meltzer, Paul S.

PY - 1994/4

Y1 - 1994/4

N2 - Amplification of 12q13-14 occurs in a subset of human sarcomas including malignant fibrous histiocytoma and liposarcoma. This chromosomal region has previously been found to include a number of growth-related genes including the GLI proto-oncogene and the p53-associated protein, MDM2. We now report the characterization of SAS (sarcoma amplified sequence), a novel transcript found in this region. Sequence analysis demonstrates that SAS is a novel member of a transmembrane protein family (transmembrane 4 superfamily or TM4SF) thought to be involved in growth-related cellular processes. This observation adds a TM4SF protein to the cluster of genes at 12q13-14 frequently amplified in human sarcomas.

AB - Amplification of 12q13-14 occurs in a subset of human sarcomas including malignant fibrous histiocytoma and liposarcoma. This chromosomal region has previously been found to include a number of growth-related genes including the GLI proto-oncogene and the p53-associated protein, MDM2. We now report the characterization of SAS (sarcoma amplified sequence), a novel transcript found in this region. Sequence analysis demonstrates that SAS is a novel member of a transmembrane protein family (transmembrane 4 superfamily or TM4SF) thought to be involved in growth-related cellular processes. This observation adds a TM4SF protein to the cluster of genes at 12q13-14 frequently amplified in human sarcomas.

UR - http://www.scopus.com/inward/record.url?scp=0028219923&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028219923&partnerID=8YFLogxK

M3 - Article

C2 - 8134123

AN - SCOPUS:0028219923

SN - 0950-9232

VL - 9

SP - 1205

EP - 1211

JO - Oncogene

JF - Oncogene

IS - 4

ER -

SAS, a gene amplified in human sarcomas, encodes a new member of the transmembrane 4 superfamily of proteins

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this