SAS, a gene amplified in human sarcomas, encodes a new member of the transmembrane 4 superfamily of proteins

Sheryl A. Jankowski, Deanna S. Mitchell, Sharon H. Smith, Jeffrey M. Trent, Paul S. Meltzer

Research output: Contribution to journalArticle

Abstract

Amplification of 12q13-14 occurs in a subset of human sarcomas including malignant fibrous histiocytoma and liposarcoma. This chromosomal region has previously been found to include a number of growth-related genes including the GLI proto-oncogene and the p53-associated protein, MDM2. We now report the characterization of SAS (sarcoma amplified sequence), a novel transcript found in this region. Sequence analysis demonstrates that SAS is a novel member of a transmembrane protein family (transmembrane 4 superfamily or TM4SF) thought to be involved in growth-related cellular processes. This observation adds a TM4SF protein to the cluster of genes at 12q13-14 frequently amplified in human sarcomas.

Original languageEnglish (US)
Pages (from-to)1205-1211
Number of pages7
JournalOncogene
Volume9
Issue number4
StatePublished - Apr 1994
Externally publishedYes

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Sarcoma
Genes
Proteins
Malignant Fibrous Histiocytoma
Liposarcoma
Proto-Oncogenes
Multigene Family
Growth
Sequence Analysis

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research
  • Genetics

Cite this

Jankowski, S. A., Mitchell, D. S., Smith, S. H., Trent, J. M., & Meltzer, P. S. (1994). SAS, a gene amplified in human sarcomas, encodes a new member of the transmembrane 4 superfamily of proteins. Oncogene, 9(4), 1205-1211.

SAS, a gene amplified in human sarcomas, encodes a new member of the transmembrane 4 superfamily of proteins. / Jankowski, Sheryl A.; Mitchell, Deanna S.; Smith, Sharon H.; Trent, Jeffrey M.; Meltzer, Paul S.

In: Oncogene, Vol. 9, No. 4, 04.1994, p. 1205-1211.

Research output: Contribution to journalArticle

Jankowski, SA, Mitchell, DS, Smith, SH, Trent, JM & Meltzer, PS 1994, 'SAS, a gene amplified in human sarcomas, encodes a new member of the transmembrane 4 superfamily of proteins', Oncogene, vol. 9, no. 4, pp. 1205-1211.
Jankowski SA, Mitchell DS, Smith SH, Trent JM, Meltzer PS. SAS, a gene amplified in human sarcomas, encodes a new member of the transmembrane 4 superfamily of proteins. Oncogene. 1994 Apr;9(4):1205-1211.
Jankowski, Sheryl A. ; Mitchell, Deanna S. ; Smith, Sharon H. ; Trent, Jeffrey M. ; Meltzer, Paul S. / SAS, a gene amplified in human sarcomas, encodes a new member of the transmembrane 4 superfamily of proteins. In: Oncogene. 1994 ; Vol. 9, No. 4. pp. 1205-1211.
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