Sarcomerogenesis in human myocardium

Marianne J. Legato

doi:10.1016/0022-2828(70)90039-8

Sarcomerogenesis in human myocardium

Marianne J. Legato

Research output: Contribution to journal › Article › peer-review

78 Scopus citations

Abstract

Myocardial tissue obtained at the time of open heart surgery from 19 patients, rat ventricular cells grown in tissue culture and atrial and ventricular tissue from newborn puppies were examined with the electron microscope in order to delineate the function of the sarcomeric Z band. The data obtained from this investigation make it apparent that Z substance is essential for the production of new sarcomeres in the myofibril, and is the source of new contractile units in situations of growth, maintenance and repair in the heart.

Original language	English (US)
Journal	Journal of Molecular and Cellular Cardiology
Volume	1
Issue number	4
DOIs	https://doi.org/10.1016/0022-2828(70)90039-8
State	Published - 1970
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Cardiology and Cardiovascular Medicine

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10.1016/0022-2828(70)90039-8

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title = "Sarcomerogenesis in human myocardium",

abstract = "Myocardial tissue obtained at the time of open heart surgery from 19 patients, rat ventricular cells grown in tissue culture and atrial and ventricular tissue from newborn puppies were examined with the electron microscope in order to delineate the function of the sarcomeric Z band. The data obtained from this investigation make it apparent that Z substance is essential for the production of new sarcomeres in the myofibril, and is the source of new contractile units in situations of growth, maintenance and repair in the heart.",

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year = "1970",

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AB - Myocardial tissue obtained at the time of open heart surgery from 19 patients, rat ventricular cells grown in tissue culture and atrial and ventricular tissue from newborn puppies were examined with the electron microscope in order to delineate the function of the sarcomeric Z band. The data obtained from this investigation make it apparent that Z substance is essential for the production of new sarcomeres in the myofibril, and is the source of new contractile units in situations of growth, maintenance and repair in the heart.

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Sarcomerogenesis in human myocardium

Abstract

ASJC Scopus subject areas

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