‘Sarcoidosis’ and Sarcoid-like Lesions: Their Occurrence After Cytotoxic and Radiation Therapy of Testis Cancer

Donald L. Trump, David S. Ettinger, Marvin J. Feldman, Leon H. Dragon

Research output: Contribution to journalArticle

Abstract

Mediastinal, paratracheal, and hilar adenopathy developed in two patients during or shortly after adjunctive cytotoxic or radiation therapy for nonseminomatous testis cancer. Lymph nodes obtained by mediastinoscopy contained multiple noncaseating granulomas with no histologic evidence of testis cancer. A Kveim test in one patient was positive. These patients were believed to have sarcoidosis with mediastinal lymphadenopathy that resolved without specific therapy. The temporal relationship between the administration of antineoplastic therapy and the development of granulomatous mediastinal adenopathy in these two patients and in one patient previously described suggests a relationship between such therapy and sarcoidosis.

Original languageEnglish (US)
Pages (from-to)37-38
Number of pages2
JournalArchives of internal medicine
Volume141
Issue number1
DOIs
StatePublished - Jan 1981

ASJC Scopus subject areas

  • Internal Medicine

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