Sarcina organisms in the gastrointestinal tract: A clinicopathologic and molecular study

Dora Lam-Himlin, Athanasios C. Tsiatis, Elizabeth A Montgomery, Rish K. Pai, J. Ahmad Brown, Mohammad Razavi, Laura Lamps, James Eshleman, Belur Bhagavan, Robert A Anders

Research output: Contribution to journalArticle

Abstract

Sarcina organisms were first observed in and recorded from the stomach contents of a patient suffering from vomiting by John Goodsir in 1842. Since that time, their fine structure, phylogenetic classification, and biochemical characteristics have been described. Although numerous cases of fatal disease have been attributed to this organism in the veterinary literature, only a few human cases have been documented. As a result, whether this organism causes disease in humans has not been definitively established. We report the clinicopathologic findings in a series of 5 patients with Sarcina-like organisms identified in upper gastrointestinal endoscopic biopsies with molecular confirmation. Our findings have shown that the organism is most commonly found in patients with a history of gastric outlet obstruction or delayed gastric emptying. Although many of the patients do not demonstrate direct mucosal injury from the organism, the presence of a concurrent gastric ulcer puts the patient at increased risk for complications such as emphysematous gastritis or perforation. The finding of Sarcina organisms should prompt further investigation for functional causes of gastric outlet obstruction and delayed gastric emptying, such as occult malignancy.

Original languageEnglish (US)
Pages (from-to)1700-1705
Number of pages6
JournalAmerican Journal of Surgical Pathology
Volume35
Issue number11
DOIs
StatePublished - Nov 2011

Fingerprint

Sarcina
Gastrointestinal Tract
Gastric Outlet Obstruction
Gastric Emptying
Gastrointestinal Contents
Gastritis
Stomach Ulcer
Vomiting
Biopsy
Wounds and Injuries
Neoplasms

Keywords

  • emphysematous gastritis
  • gastritis
  • gastrointestinal tract
  • gastroparesis
  • Sarcina

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine
  • Surgery

Cite this

Sarcina organisms in the gastrointestinal tract : A clinicopathologic and molecular study. / Lam-Himlin, Dora; Tsiatis, Athanasios C.; Montgomery, Elizabeth A; Pai, Rish K.; Brown, J. Ahmad; Razavi, Mohammad; Lamps, Laura; Eshleman, James; Bhagavan, Belur; Anders, Robert A.

In: American Journal of Surgical Pathology, Vol. 35, No. 11, 11.2011, p. 1700-1705.

Research output: Contribution to journalArticle

Lam-Himlin, Dora ; Tsiatis, Athanasios C. ; Montgomery, Elizabeth A ; Pai, Rish K. ; Brown, J. Ahmad ; Razavi, Mohammad ; Lamps, Laura ; Eshleman, James ; Bhagavan, Belur ; Anders, Robert A. / Sarcina organisms in the gastrointestinal tract : A clinicopathologic and molecular study. In: American Journal of Surgical Pathology. 2011 ; Vol. 35, No. 11. pp. 1700-1705.
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