SAR of tertiary carbinamine derived BACE1 inhibitors: Role of aspartate ligand amine pKa in enzyme inhibition

Hemaka A. Rajapakse, Philippe G. Nantermet, Harold G. Selnick, James C. Barrow, Georgia B. McGaughey, Sanjeev Munshi, Stacey R. Lindsley, Mary Beth Young, Phung L. Ngo, M. Katherine Holloway, Ming Tain Lai, Amy S. Espeseth, Xiao Ping Shi, Dennis Colussi, Beth Pietrak, Ming Chih Crouthamel, Katherine Tugusheva, Qian Huang, Min Xu, Adam J. SimonLawrence Kuo, Daria J. Hazuda, Samuel Graham, Joseph P. Vacca

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