SAR of cocaine: further exploration of structural variations at the C-2 center provides compounds of subnanomolar binding potency

Alan P. Kozikowski; Marinella Roberti; Kenneth M. Johnson; John S. Bergmann; Richard G. Ball

doi:10.1016/S0960-894X(00)80341-8

SAR of cocaine: further exploration of structural variations at the C-2 center provides compounds of subnanomolar binding potency

Alan P. Kozikowski, Marinella Roberti, Kenneth M. Johnson, John S. Bergmann, Richard G. Ball

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Syntheses of a variety of new analogues of cocaine are reported together with their binding affinities and dopamine uptake inhibition activities. The present work further expands the SAR data base for cocaine.

Original language	English (US)
Pages (from-to)	1327-1332
Number of pages	6
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	3
Issue number	6
DOIs	https://doi.org/10.1016/S0960-894X(00)80341-8
State	Published - Jun 1993
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/S0960-894X(00)80341-8

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title = "SAR of cocaine: further exploration of structural variations at the C-2 center provides compounds of subnanomolar binding potency",

abstract = "Syntheses of a variety of new analogues of cocaine are reported together with their binding affinities and dopamine uptake inhibition activities. The present work further expands the SAR data base for cocaine.",

author = "Kozikowski, {Alan P.} and Marinella Roberti and Johnson, {Kenneth M.} and Bergmann, {John S.} and Ball, {Richard G.}",

year = "1993",

month = jun,

doi = "10.1016/S0960-894X(00)80341-8",

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journal = "Bioorganic and Medicinal Chemistry Letters",

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T1 - SAR of cocaine

T2 - further exploration of structural variations at the C-2 center provides compounds of subnanomolar binding potency

AU - Kozikowski, Alan P.

AU - Roberti, Marinella

AU - Johnson, Kenneth M.

AU - Bergmann, John S.

AU - Ball, Richard G.

PY - 1993/6

Y1 - 1993/6

N2 - Syntheses of a variety of new analogues of cocaine are reported together with their binding affinities and dopamine uptake inhibition activities. The present work further expands the SAR data base for cocaine.

AB - Syntheses of a variety of new analogues of cocaine are reported together with their binding affinities and dopamine uptake inhibition activities. The present work further expands the SAR data base for cocaine.

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U2 - 10.1016/S0960-894X(00)80341-8

DO - 10.1016/S0960-894X(00)80341-8

M3 - Article

AN - SCOPUS:0027278546

SN - 0960-894X

VL - 3

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EP - 1332

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 6

ER -

SAR of cocaine: further exploration of structural variations at the C-2 center provides compounds of subnanomolar binding potency

Abstract

ASJC Scopus subject areas

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