SAR of cocaine: further exploration of structural variations at the C-2 center provides compounds of subnanomolar binding potency

Alan P. Kozikowski, Marinella Roberti, Kenneth M. Johnson, John S. Bergmann, Richard G. Ball

Research output: Contribution to journalArticle


Syntheses of a variety of new analogues of cocaine are reported together with their binding affinities and dopamine uptake inhibition activities. The present work further expands the SAR data base for cocaine.

Original languageEnglish (US)
Pages (from-to)1327-1332
Number of pages6
JournalBioorganic and Medicinal Chemistry Letters
Issue number6
Publication statusPublished - 1993
Externally publishedYes


ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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