Sample-to-result molecular infectious disease assays: Clinical implications, limitations and potential

Stacy G. Beal; Naziheh Assarzadegan; Kenneth H. Rand

doi:10.1586/14737159.2016.1134325

Sample-to-result molecular infectious disease assays: Clinical implications, limitations and potential

Stacy G. Beal, Naziheh Assarzadegan, Kenneth H. Rand

Research output: Contribution to journal › Review article › peer-review

5 Scopus citations

Abstract

Molecular infectious disease diagnostic tests have undergone major advances in the past decade and will continue to rapidly evolve. Assays have become extraordinarily simple to perform, eliminating the need for pre-analytic sample preparation and post-amplification analysis. This allows these tests to be performed in settings without sophisticated expertise in molecular biology, including locations with limited resources. Additionally, the sensitivity and specificity of these assays is superb and many offer extremely fast turn-around times. These tests have major impacts on patient care, but also have some limitations.

Original language	English (US)
Pages (from-to)	323-341
Number of pages	19
Journal	Expert Review of Molecular Diagnostics
Volume	16
Issue number	3
DOIs	https://doi.org/10.1586/14737159.2016.1134325
State	Published - Mar 3 2016
Externally published	Yes

Keywords

Infectious disease testing
microbiology
molecular testing
nucleic acid tests
rapid testing
sample to answer
sample to result
undeveloped countries

ASJC Scopus subject areas

Pathology and Forensic Medicine
Molecular Medicine
Molecular Biology
Genetics

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title = "Sample-to-result molecular infectious disease assays: Clinical implications, limitations and potential",

abstract = "Molecular infectious disease diagnostic tests have undergone major advances in the past decade and will continue to rapidly evolve. Assays have become extraordinarily simple to perform, eliminating the need for pre-analytic sample preparation and post-amplification analysis. This allows these tests to be performed in settings without sophisticated expertise in molecular biology, including locations with limited resources. Additionally, the sensitivity and specificity of these assays is superb and many offer extremely fast turn-around times. These tests have major impacts on patient care, but also have some limitations.",

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AU - Assarzadegan, Naziheh

AU - Rand, Kenneth H.

PY - 2016/3/3

Y1 - 2016/3/3

N2 - Molecular infectious disease diagnostic tests have undergone major advances in the past decade and will continue to rapidly evolve. Assays have become extraordinarily simple to perform, eliminating the need for pre-analytic sample preparation and post-amplification analysis. This allows these tests to be performed in settings without sophisticated expertise in molecular biology, including locations with limited resources. Additionally, the sensitivity and specificity of these assays is superb and many offer extremely fast turn-around times. These tests have major impacts on patient care, but also have some limitations.

AB - Molecular infectious disease diagnostic tests have undergone major advances in the past decade and will continue to rapidly evolve. Assays have become extraordinarily simple to perform, eliminating the need for pre-analytic sample preparation and post-amplification analysis. This allows these tests to be performed in settings without sophisticated expertise in molecular biology, including locations with limited resources. Additionally, the sensitivity and specificity of these assays is superb and many offer extremely fast turn-around times. These tests have major impacts on patient care, but also have some limitations.

KW - Infectious disease testing

KW - microbiology

KW - molecular testing

KW - nucleic acid tests

KW - rapid testing

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KW - sample to result

KW - undeveloped countries

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Sample-to-result molecular infectious disease assays: Clinical implications, limitations and potential

Abstract

Keywords

ASJC Scopus subject areas

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