Sample size and power calculation in comparing diagnostic accuracy of biomarkers with pooled assessments

Aiyi Liu, Enrique F. Schisterman, Eric Teoh

Research output: Contribution to journalArticle

Abstract

When testing of a biomarker is costly, pooling of samples becomes a useful and efficient alternative (Faraggi et al., 2003). In this paper, we develop procedures for sample size and power calculations for planning a study comparing the accuracy of biomarkers in diagnosis of diseases with pooled samples. Explicit formulas are derived for several important pooling strategies. The effects of pooling samples on sample size and power of the test are also discussed.

Original languageEnglish (US)
Pages (from-to)49-59
Number of pages11
JournalJournal of Applied Statistics
Volume31
Issue number1
DOIs
StatePublished - Jan 2004
Externally publishedYes

Keywords

  • Area under the curve
  • Diagnostic biomarkers
  • Receiver operating characteristic curves
  • Sensitivity
  • Specificity

ASJC Scopus subject areas

  • Statistics and Probability

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