Sam68 Offers Selectively Aimed Modulation of Transcription in Cancer Stem Cells

Kai Fu; Fengyi Wan

doi:10.1016/j.chembiol.2017.07.003

Sam68 Offers Selectively Aimed Modulation of Transcription in Cancer Stem Cells

Kai Fu, Fengyi Wan

Bloomberg School of Public Health

Research output: Contribution to journal › Short survey › peer-review

2 Scopus citations

Abstract

In this issue of Cell Chemical Biology, Benoit et al. (2017) report the selective targeting of cancer stem cells (CSCs) by the ICG-001/CWP family of molecules. Their findings reveal that Sam68 is a transcriptional modulator uniquely required for the dysregulated Wnt/β-catenin signaling in CSCs over healthy stem cells.

Original language	English (US)
Pages (from-to)	777-779
Number of pages	3
Journal	Cell Chemical Biology
Volume	24
Issue number	7
DOIs	https://doi.org/10.1016/j.chembiol.2017.07.003
State	Published - Jul 20 2017

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmacology
Drug Discovery
Clinical Biochemistry

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10.1016/j.chembiol.2017.07.003

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title = "Sam68 Offers Selectively Aimed Modulation of Transcription in Cancer Stem Cells",

abstract = "In this issue of Cell Chemical Biology, Benoit et al. (2017) report the selective targeting of cancer stem cells (CSCs) by the ICG-001/CWP family of molecules. Their findings reveal that Sam68 is a transcriptional modulator uniquely required for the dysregulated Wnt/β-catenin signaling in CSCs over healthy stem cells.",

author = "Kai Fu and Fengyi Wan",

note = "Funding Information: This work was supported by the American Cancer Society (RSG-13-052-01-MPC to F.W.) and the National Institutes of Health (R01GM111682 to F.W.). We thank Danielle Bouchard for editorial assistance. Publisher Copyright: {\textcopyright} 2017 Elsevier Ltd",

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doi = "10.1016/j.chembiol.2017.07.003",

language = "English (US)",

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journal = "Cell Chemical Biology",

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T1 - Sam68 Offers Selectively Aimed Modulation of Transcription in Cancer Stem Cells

AU - Fu, Kai

AU - Wan, Fengyi

N1 - Funding Information: This work was supported by the American Cancer Society (RSG-13-052-01-MPC to F.W.) and the National Institutes of Health (R01GM111682 to F.W.). We thank Danielle Bouchard for editorial assistance. Publisher Copyright: © 2017 Elsevier Ltd

PY - 2017/7/20

Y1 - 2017/7/20

N2 - In this issue of Cell Chemical Biology, Benoit et al. (2017) report the selective targeting of cancer stem cells (CSCs) by the ICG-001/CWP family of molecules. Their findings reveal that Sam68 is a transcriptional modulator uniquely required for the dysregulated Wnt/β-catenin signaling in CSCs over healthy stem cells.

AB - In this issue of Cell Chemical Biology, Benoit et al. (2017) report the selective targeting of cancer stem cells (CSCs) by the ICG-001/CWP family of molecules. Their findings reveal that Sam68 is a transcriptional modulator uniquely required for the dysregulated Wnt/β-catenin signaling in CSCs over healthy stem cells.

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DO - 10.1016/j.chembiol.2017.07.003

M3 - Short survey

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VL - 24

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EP - 779

JO - Cell Chemical Biology

JF - Cell Chemical Biology

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ER -

Sam68 Offers Selectively Aimed Modulation of Transcription in Cancer Stem Cells

Abstract

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