Sam68 is required for the growth and survival of nonmelanoma skin cancer

Kai Fu, Xin Sun, Xue Xia, Ryan P. Hobbs, Yajuan Guo, Pierre A. Coulombe, Fengyi Wan

Research output: Contribution to journalArticle

Abstract

Although targeting DNA repair signaling pathways has emerged as a promising therapeutic for skin cancer, the relevance of DNA damage responses (DDR) in the development and survival of nonmelanoma skin cancer (NMSC), the most common type of skin cancer, remains obscure. Here, we report that Src-associated substrate during mitosis of 68 kDa (Sam68), an early signaling molecule in DDR, is elevated in skin tumor tissues derived from NMSC patients and skin lesions from Gli2-transgenic mice. Downregulation of Sam68 impacts the growth and survival of human tumor keratinocytes and genetic ablation of Sam68 delays the onset of basal cell carcinomas (BCC) in Gli2-transgenic mice. Moreover, Sam68 plays a critical role in DNA damage-induced DNA repair and nuclear factor kappa B (NF-κB) signaling pathways in keratinocytes, hence conferring keratinocyte sensitivity to DNA damaging agents. Together, our data reveal a novel function of Sam68 in regulating DDR in keratinocytes that is crucial for the growth and survival of NMSC.

Original languageEnglish (US)
Pages (from-to)6106-6113
Number of pages8
JournalCancer medicine
Volume8
Issue number13
DOIs
StatePublished - Oct 1 2019

Keywords

  • DNA damage responses
  • NF-κB
  • Sam68
  • skin cancer

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Fingerprint Dive into the research topics of 'Sam68 is required for the growth and survival of nonmelanoma skin cancer'. Together they form a unique fingerprint.

Cite this