Salivary cortisol and soluble tumor necrosis factor-α receptor II responses to multiple experimental modalities of acute pain

Burel R. Goodin, Noel B. Quinn, Christopher D. King, Gayle G. Page, Jennifer A. Haythornthwaite, Robert R. Edwards, Laura Stapleton, Lynanne Mcguire

Research output: Contribution to journalArticlepeer-review

Abstract

The present study compared cortisol and soluble tumor necrosis factor-α receptor II (sTNFαRII) responses provoked by cold pressor, hot water, ischemic, and neutral water (i.e., room temperature) modalities. Oral fluid samples were collected before, immediately after, and during recovery to assess physiological responses. From baseline, the cold pressor, but not hot water or ischemic modalities, produced a significant time-dependent elevation in cortisol, whereas cortisol significantly decreased for the neutral water task. When compared to baseline, the cold pressor, hot water, and ischemic modalities were associated with decreased sTNFαRII responses over time. The sTNFαRII response to neutral water initially decreased but returned to approximate baseline levels. Pain ratings were positively associated with cortisol increase from baseline and the overall cortisol response was negatively associated with the overall sTNFαRII response.

Original languageEnglish (US)
Pages (from-to)118-127
Number of pages10
JournalPSYCHOPHYSIOLOGY
Volume49
Issue number1
DOIs
StatePublished - Jan 2012

Keywords

  • Biochemical
  • Immunology
  • Normal volunteers
  • Pain
  • Sensation/perception

ASJC Scopus subject areas

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology
  • Experimental and Cognitive Psychology
  • Neurology
  • Endocrine and Autonomic Systems
  • Developmental Neuroscience
  • Cognitive Neuroscience
  • Biological Psychiatry

Fingerprint Dive into the research topics of 'Salivary cortisol and soluble tumor necrosis factor-α receptor II responses to multiple experimental modalities of acute pain'. Together they form a unique fingerprint.

Cite this