Salicylic Acid Conjugated Dendrimers Are a Tunable, High Performance CEST MRI NanoPlatform

Research output: Contribution to journalArticle

Abstract

Chemical exchange saturation transfer (CEST) is a novel MRI contrast mechanism that is well suited for imaging, however, existing small molecule CEST agents suffer from low sensitivity. We have developed salicylic acid conjugated dendrimers as a versatile, high performance nanoplatform. In particular, we have prepared nanocarriers based on generation 5-poly(amidoamine) (PAMAM) dendrimers with salicylic acid covalently attached to their surface. The resulting conjugates produce strong CEST contrast 9.4 ppm from water with the proton exchange tunable from ∼1000 s-1 to ∼4500 s-1 making these dendrimers well suited for sensitive detection. Furthermore, we demonstrate that these conjugates can be used for monitoring convection enhanced delivery into U87 glioblastoma bearing mice, with the contrast produced by these nanoparticles persisting for over 1.5 h and distributed over ∼50% of the tumors. Our results demonstrate that SA modified dendrimers present a promising new nanoplatform for medical applications.

Original languageEnglish (US)
Pages (from-to)2248-2253
Number of pages6
JournalNano Letters
Volume16
Issue number4
DOIs
StatePublished - Apr 13 2016

Fingerprint

dendrimers
Dendrimers
saturation
acids
Salicylic acid
Magnetic resonance imaging
Edema Disease of Swine
Inborn Errors Amino Acid Metabolism
Antimony Potassium Tartrate
Adenofibroma
Chronic Mucocutaneous Candidiasis
Contraception Behavior
Convection
Medical applications
Myosins
Molecules
mice
delivery
convection
tumors

Keywords

  • CED
  • chemical exchange saturation transfer (CEST)
  • dendrimers
  • glioblastoma
  • salicylic acid

ASJC Scopus subject areas

  • Condensed Matter Physics
  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Mechanical Engineering

Cite this

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title = "Salicylic Acid Conjugated Dendrimers Are a Tunable, High Performance CEST MRI NanoPlatform",
abstract = "Chemical exchange saturation transfer (CEST) is a novel MRI contrast mechanism that is well suited for imaging, however, existing small molecule CEST agents suffer from low sensitivity. We have developed salicylic acid conjugated dendrimers as a versatile, high performance nanoplatform. In particular, we have prepared nanocarriers based on generation 5-poly(amidoamine) (PAMAM) dendrimers with salicylic acid covalently attached to their surface. The resulting conjugates produce strong CEST contrast 9.4 ppm from water with the proton exchange tunable from ∼1000 s-1 to ∼4500 s-1 making these dendrimers well suited for sensitive detection. Furthermore, we demonstrate that these conjugates can be used for monitoring convection enhanced delivery into U87 glioblastoma bearing mice, with the contrast produced by these nanoparticles persisting for over 1.5 h and distributed over ∼50% of the tumors. Our results demonstrate that SA modified dendrimers present a promising new nanoplatform for medical applications.",
keywords = "CED, chemical exchange saturation transfer (CEST), dendrimers, glioblastoma, salicylic acid",
author = "Lesniak, {Wojciech G.} and Nikita Oskolkov and Xiaolei Song and Bachchu Lal and Xing Yang and Martin Pomper and John Laterra and Sridhar Nimmagadda and McMahon, {Michael T.}",
year = "2016",
month = "4",
doi = "10.1021/acs.nanolett.5b04517",
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AU - Lesniak,Wojciech G.

AU - Oskolkov,Nikita

AU - Song,Xiaolei

AU - Lal,Bachchu

AU - Yang,Xing

AU - Pomper,Martin

AU - Laterra,John

AU - Nimmagadda,Sridhar

AU - McMahon,Michael T.

PY - 2016/4/13

Y1 - 2016/4/13

N2 - Chemical exchange saturation transfer (CEST) is a novel MRI contrast mechanism that is well suited for imaging, however, existing small molecule CEST agents suffer from low sensitivity. We have developed salicylic acid conjugated dendrimers as a versatile, high performance nanoplatform. In particular, we have prepared nanocarriers based on generation 5-poly(amidoamine) (PAMAM) dendrimers with salicylic acid covalently attached to their surface. The resulting conjugates produce strong CEST contrast 9.4 ppm from water with the proton exchange tunable from ∼1000 s-1 to ∼4500 s-1 making these dendrimers well suited for sensitive detection. Furthermore, we demonstrate that these conjugates can be used for monitoring convection enhanced delivery into U87 glioblastoma bearing mice, with the contrast produced by these nanoparticles persisting for over 1.5 h and distributed over ∼50% of the tumors. Our results demonstrate that SA modified dendrimers present a promising new nanoplatform for medical applications.

AB - Chemical exchange saturation transfer (CEST) is a novel MRI contrast mechanism that is well suited for imaging, however, existing small molecule CEST agents suffer from low sensitivity. We have developed salicylic acid conjugated dendrimers as a versatile, high performance nanoplatform. In particular, we have prepared nanocarriers based on generation 5-poly(amidoamine) (PAMAM) dendrimers with salicylic acid covalently attached to their surface. The resulting conjugates produce strong CEST contrast 9.4 ppm from water with the proton exchange tunable from ∼1000 s-1 to ∼4500 s-1 making these dendrimers well suited for sensitive detection. Furthermore, we demonstrate that these conjugates can be used for monitoring convection enhanced delivery into U87 glioblastoma bearing mice, with the contrast produced by these nanoparticles persisting for over 1.5 h and distributed over ∼50% of the tumors. Our results demonstrate that SA modified dendrimers present a promising new nanoplatform for medical applications.

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KW - glioblastoma

KW - salicylic acid

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