Safety profile and utility of treadmill exercise in patients with high-gradient hypertrophic cardiomyopathy

Lars Lindholm Sorensen, Hsin Yueh Liang, Aurelio Pinheiro, Alex Hilser, Veronica Dimaano, Niels Thue Olsen, Thomas Fritz Hansen, Peter Sogaard, Alexandra Nowbar, Chiara Pisanello, Iraklis Pozios, Susan Phillip, Xun Zhou, Roselle Abraham, Theodore P. Abraham

Research output: Contribution to journalArticlepeer-review


Exercise echocardiography in the evaluation of hypertrophic cardiomyopathy (HCM) provides valuable information for risk stratification, selection of optimal treatment, and prognostication. However, HCM patients with left ventricular outflow tract gradients ≥30 mm Hg are often excluded from exercise testing because of safety considerations. We examined the safety and utility of exercise testing in patients with high-gradient HCM. Methods We evaluated clinical characteristics, hemodynamics, and imaging variables in 499 consecutive patients with HCM who performed 959 exercise tests. Patients were divided based on peak left ventricular outflow tract gradients using a 30-mm Hg threshold into the following: obstructive (n = 152), labile-obstructive (n = 178), and nonobstructive (n = 169) groups. Results There were no deaths during exercise testing. We noted 20 complications (2.1% of tests) including 3 serious ventricular arrhythmias (0.3% of tests). There was no difference in complication rate between groups. Patients with obstructive HCM had a higher frequency of abnormal blood pressure response (obstructive: 53% vs labile: obstructive: 41% and nonobstructive: 37%; P = .008). Obstructive patients also displayed a lower work capacity (obstructive: 8.4 ± 3.4 vs labile obstructive: 10.9 ± 4.2 and nonobstructive: 10.2 ± 4.0, metabolic equivalent; P < .001). Exercise testing provided incremental information regarding sudden cardiac death risk in 19% of patients with high-gradient HCM, and we found a poor correlation between patient-reported functional class and work capacity. Conclusion Our results suggest that exercise testing in HCM is safe, and serious adverse events are rare. Although numbers are limited, exercise testing in high-gradient HCM appears to confer no significant additional safety hazard in our selected cohort and could potentially provide valuable information.

Original languageEnglish (US)
Pages (from-to)47-54
Number of pages8
JournalAmerican heart journal
StatePublished - Feb 1 2017

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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