TY - JOUR
T1 - Safety of Sabin Oral Poliovaccine Strains
T2 - Mass Immunization Program in Los Angeles County, 1962-1963
AU - Wehrle, Paul F.
AU - Leedom, John M.
AU - Portnoy, Bernard
AU - Pierce, Nathaniel F.
AU - Cowper, Herbert H.
PY - 1963/11/30
Y1 - 1963/11/30
N2 - In a mass immunization program, over 7.5 million doses of Sabin oral poliovaccine (OPV, types 1, 2, and 3) were administered in Los Angeles County in 1962 and 1963, during a period of declining and low enterovirus prevalence. Clinical and laboratory surveillance failed to demonstrate vaccine-associated illness. It seems highly unlikely that the 5 to 21 cases of paralytic poliomyelitis expected on the basis of “maximal expected risk” could have been overlooked. A reasonable explanation for the apparent disparity between Los Angeles County and certain other areas in safety of OPV is that other agents were present elsewhere which produced disease independently or in concert with OPV.
AB - In a mass immunization program, over 7.5 million doses of Sabin oral poliovaccine (OPV, types 1, 2, and 3) were administered in Los Angeles County in 1962 and 1963, during a period of declining and low enterovirus prevalence. Clinical and laboratory surveillance failed to demonstrate vaccine-associated illness. It seems highly unlikely that the 5 to 21 cases of paralytic poliomyelitis expected on the basis of “maximal expected risk” could have been overlooked. A reasonable explanation for the apparent disparity between Los Angeles County and certain other areas in safety of OPV is that other agents were present elsewhere which produced disease independently or in concert with OPV.
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U2 - 10.1001/jama.1963.03710090021004
DO - 10.1001/jama.1963.03710090021004
M3 - Article
C2 - 14061062
AN - SCOPUS:75449142939
SN - 0098-7484
VL - 186
SP - 821
EP - 826
JO - JAMA - Journal of the American Medical Association
JF - JAMA - Journal of the American Medical Association
IS - 9
ER -