Safety of Sabin Oral Poliovaccine Strains: Mass Immunization Program in Los Angeles County, 1962-1963

Paul F. Wehrle, John M. Leedom, Bernard Portnoy, Nathaniel F. Pierce, Herbert H. Cowper

Research output: Contribution to journalArticlepeer-review

Abstract

In a mass immunization program, over 7.5 million doses of Sabin oral poliovaccine (OPV, types 1, 2, and 3) were administered in Los Angeles County in 1962 and 1963, during a period of declining and low enterovirus prevalence. Clinical and laboratory surveillance failed to demonstrate vaccine-associated illness. It seems highly unlikely that the 5 to 21 cases of paralytic poliomyelitis expected on the basis of “maximal expected risk” could have been overlooked. A reasonable explanation for the apparent disparity between Los Angeles County and certain other areas in safety of OPV is that other agents were present elsewhere which produced disease independently or in concert with OPV.

Original languageEnglish (US)
Pages (from-to)821-826
Number of pages6
JournalJAMA: The Journal of the American Medical Association
Volume186
Issue number9
DOIs
StatePublished - Nov 30 1963
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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